| Literature DB >> 21810450 |
Allen C Cheng1, Tom Kotsimbos, Heath A Kelly, Louis B Irving, Simon D Bowler, Simon G A Brown, Mark Holmes, Christine R Jenkins, Philip Thompson, Graham Simpson, Richard Wood-Baker, Sanjaya N Senanayake, Stephen J Brady, David L Paterson, Peter A Wark, John W Upham, Tony M Korman, Dominic E Dwyer, Grant W Waterer, Paul M Kelly.
Abstract
We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21810450 DOI： 10.1016/j.vaccine.2011.07.087
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641