Literature DB >> 21805

Peptido-aminobenzophenones--novel latentiated benzo-1,4-diazepines.

C H Hassall, S W Holmes, W H Johnson, A Kröhn, C E Smithen, W A Thomas.   

Abstract

It has been shown that cleavage of the N-terminal L-amino acids of a novel series of dipeptide derivatives of 2-aminobenzophenones occurs readily in vivo to give benzo-1,4-diazepines. Such compounds may serve as useful pro-drug forms of minor tranquilizers such as Valium.

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Year:  1977        PMID: 21805     DOI: 10.1007/BF01918828

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  1 in total

Review 1.  1,4-benzodiazepines. Chemistry and some aspects of the structure-activity relationship.

Authors:  L H Sternbach
Journal:  Angew Chem Int Ed Engl       Date:  1971-01       Impact factor: 15.336

  1 in total

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