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Literature DB >> 21804860

Weight Loss as a Cure for Type 2 Diabetes? Fact or Fantasy.

Sangeeta R Kashyap¹, Emily S Louis, John P Kirwan.

Abstract

Although individuals with obesity and type 2 diabetes are insulin resistant, pancreatic beta cell failure is the core defect that distinguishes individuals who eventually develop diabetes. This process is known to occur well before the onset of hyperglycemia. Although clinical trial data support the effectiveness of intensive lifestyle modification in delaying the onset of diabetes in obese subjects, less is known about the effects of and mechanisms underlying bariatric surgery, particularly gastric bypass surgery, on diabetes. The paper under evaluation clarifies the role of both lifestyle intervention and gastric bypass surgery on pancreatic beta cell function and raises questions regarding the role of weight loss versus incretin related mechanisms on recovery of beta cell failure.

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 21804860 PMCID： PMC3145356 DOI： 10.1586/eem.11.42

Source DB: PubMed Journal: Expert Rev Endocrinol Metab ISSN： 1744-6651

27 in total

1. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus.

Authors: C Bogardus; E Ravussin; D C Robbins; R R Wolfe; E S Horton; E A Sims
Journal: Diabetes Date: 1984-04 Impact factor: 9.461

2. A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans.

Authors: Thomas Pj Solomon; Jacob M Haus; Karen R Kelly; Marc D Cook; Julianne Filion; Michael Rocco; Sangeeta R Kashyap; Richard M Watanabe; Hope Barkoukis; John P Kirwan
Journal: Am J Clin Nutr Date: 2010-10-27 Impact factor: 7.045

3. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity.

Authors: Karen R Kelly; Latina M Brooks; Thomas P J Solomon; Sangeeta R Kashyap; Valerie B O'Leary; John P Kirwan
Journal: Am J Physiol Endocrinol Metab Date: 2009-04-07 Impact factor: 4.310

Review 4. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM.

Authors: R R Henry; B Gumbiner
Journal: Diabetes Care Date: 1991-09 Impact factor: 19.112

5. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial.

Authors: Xavier Pi-Sunyer; George Blackburn; Frederick L Brancati; George A Bray; Renee Bright; Jeanne M Clark; Jeffrey M Curtis; Mark A Espeland; John P Foreyt; Kathryn Graves; Steven M Haffner; Barbara Harrison; James O Hill; Edward S Horton; John Jakicic; Robert W Jeffery; Karen C Johnson; Steven Kahn; David E Kelley; Abbas E Kitabchi; William C Knowler; Cora E Lewis; Barbara J Maschak-Carey; Brenda Montgomery; David M Nathan; Jennifer Patricio; Anne Peters; J Bruce Redmon; Rebecca S Reeves; Donna H Ryan; Monika Safford; Brent Van Dorsten; Thomas A Wadden; Lynne Wagenknecht; Jacqueline Wesche-Thobaben; Rena R Wing; Susan Z Yanovski
Journal: Diabetes Care Date: 2007-03-15 Impact factor: 19.112

Review 6. Pathogenesis of type 2 diabetes mellitus.

Authors: Ralph A DeFronzo
Journal: Med Clin North Am Date: 2004-07 Impact factor: 5.456

7. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding.

Authors: Judith Korner; Marc Bessler; William Inabnet; Carmen Taveras; Jens Juul Holst
Journal: Surg Obes Relat Dis Date: 2007-10-23 Impact factor: 4.734

8. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance.

Authors: Kirsten Vollmer; Jens J Holst; Birgit Baller; Mark Ellrichmann; Michael A Nauck; Wolfgang E Schmidt; Juris J Meier
Journal: Diabetes Date: 2007-12-05 Impact factor: 9.461

9. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters.

Authors: Carel W le Roux; Simon J B Aylwin; Rachel L Batterham; Cynthia M Borg; Frances Coyle; Vyas Prasad; Sandra Shurey; Mohammad A Ghatei; Ameet G Patel; Stephen R Bloom
Journal: Ann Surg Date: 2006-01 Impact factor: 12.969

10. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.

Authors: Ralph A Defronzo
Journal: Diabetes Date: 2009-04 Impact factor: 9.461

3 in total