BACKGROUND AND PURPOSE: A growing body of evidence suggests the involvement of the brain in FM. The purpose of this proton MRS study was to test the hypothesis that there are metabolic alterations in some brain regions processing pain (VLPFC and thalamus) in patients with FM compared with HC. MATERIALS AND METHODS: Twelve patients with FM (30-54 years of age; mean age, 43.2 years), and 12 HC, matched for age and sex, underwent 1 session of single-voxel MRS performed on a 3T MR imaging scanner. MRS spectra were acquired with a PRESS for localization. The raw data from each spectrum was evaluated with an LCModel. T tests were used to evaluate differences of brain metabolites between groups. The Pearson correlation tested the relationship of metabolite ratios and clinical symptoms. RESULTS: Glx/Cr and Glu/Cr ratios within the VLPFC of both sides were significantly higher in patients than in HC (P < .01). No significant differences of metabolites between groups were found in the thalami. Positive correlations were found between Glu/Cr in the left thalamus and the VAS for pain (r = 0.730, P = .007) and between mIns/Cr in the right VLPFC and the VAS for pain (r = 0.607, P = .037) and the FIQ (r = 0.719, P = .008). CONCLUSIONS: The presence of elevated Glu/Cr levels in VLPFC strengthens the opinion that a complex neurophysiologic imbalance of different brain areas involved in pain processing underlies FM. These data may be useful in the diagnosis and development of more effective pharmacologic treatments.
BACKGROUND AND PURPOSE: A growing body of evidence suggests the involvement of the brain in FM. The purpose of this proton MRS study was to test the hypothesis that there are metabolic alterations in some brain regions processing pain (VLPFC and thalamus) in patients with FM compared with HC. MATERIALS AND METHODS: Twelve patients with FM (30-54 years of age; mean age, 43.2 years), and 12 HC, matched for age and sex, underwent 1 session of single-voxel MRS performed on a 3T MR imaging scanner. MRS spectra were acquired with a PRESS for localization. The raw data from each spectrum was evaluated with an LCModel. T tests were used to evaluate differences of brain metabolites between groups. The Pearson correlation tested the relationship of metabolite ratios and clinical symptoms. RESULTS: Glx/Cr and Glu/Cr ratios within the VLPFC of both sides were significantly higher in patients than in HC (P < .01). No significant differences of metabolites between groups were found in the thalami. Positive correlations were found between Glu/Cr in the left thalamus and the VAS for pain (r = 0.730, P = .007) and between mIns/Cr in the right VLPFC and the VAS for pain (r = 0.607, P = .037) and the FIQ (r = 0.719, P = .008). CONCLUSIONS: The presence of elevated Glu/Cr levels in VLPFC strengthens the opinion that a complex neurophysiologic imbalance of different brain areas involved in pain processing underlies FM. These data may be useful in the diagnosis and development of more effective pharmacologic treatments.
Authors: Eric Guedj; David Taieb; Serge Cammilleri; David Lussato; Catherine de Laforte; Jean Niboyet; Olivier Mundler Journal: Eur J Nucl Med Mol Imaging Date: 2006-08-25 Impact factor: 9.236
Authors: J M Mountz; L A Bradley; J G Modell; R W Alexander; M Triana-Alexander; L A Aaron; K E Stewart; G S Alarcón; J D Mountz Journal: Arthritis Rheum Date: 1995-07
Authors: Nicolas Fayed; Javier Garcia-Campayo; Rosa Magallón; Helena Andrés-Bergareche; Juan V Luciano; Eva Andres; Julián Beltrán Journal: Arthritis Res Ther Date: 2010-07-07 Impact factor: 5.156
Authors: Matthew D Lieberman; Johanna M Jarcho; Steve Berman; Bruce D Naliboff; Brandall Y Suyenobu; Mark Mandelkern; Emeran A Mayer Journal: Neuroimage Date: 2004-05 Impact factor: 6.556
Authors: M Petrou; R E Harris; B R Foerster; S A McLean; A Sen; D J Clauw; P C Sundgren Journal: AJNR Am J Neuroradiol Date: 2008-03-13 Impact factor: 3.825
Authors: Patrick B Wood; Christina R Ledbetter; Michael F Glabus; Larry K Broadwell; James C Patterson Journal: J Pain Date: 2008-09-04 Impact factor: 5.820
Authors: Marco L Loggia; Chantal Berna; Jieun Kim; Christine M Cahalan; Marc-Olivier Martel; Randy L Gollub; Ajay D Wasan; Vitaly Napadow; Robert R Edwards Journal: J Pain Date: 2015-04-30 Impact factor: 5.820
Authors: Marcel Simis; Jay S Reidler; Debora Duarte Macea; Ingrid Moreno Duarte; Xiaoen Wang; Robert Lenkinski; John C Petrozza; Felipe Fregni Journal: Pain Pract Date: 2014-05-02 Impact factor: 3.183
Authors: Maarten Moens; Peter Mariën; Raf Brouns; Jan Poelaert; Ann De Smedt; Ronald Buyl; Steven Droogmans; Peter Van Schuerbeek; Stefan Sunaert; Bart Nuttin Journal: Neuroradiology Date: 2013-05-12 Impact factor: 2.804
Authors: Jeungchan Lee; Ovidiu C Andronesi; Angel Torrado-Carvajal; Eva-Maria Ratai; Marco L Loggia; Akila Weerasekera; Michael P Berry; Dan-Mikael Ellingsen; Laura Isaro; Asimina Lazaridou; Myrella Paschali; Arvina Grahl; Ajay D Wasan; Robert R Edwards; Vitaly Napadow Journal: Eur J Pain Date: 2021-06-22 Impact factor: 3.651