PURPOSE: Neuro-imaging studies with (99m)Tc-HMPAO SPECT in fibromyalgia (FM) patients have reported only limited subcortical hypoperfusion. (99m)Tc-ECD SPECT is known to provide better evaluation of areas of high cerebral blood flow and regional metabolic rate. We evaluated a homogeneous group of hyperalgesic patients with FM using (99m)Tc-ECD SPECT. The aim of this study was to investigate brain processing associated with spontaneous pain in FM patients. METHODS: Eighteen hyperalgesic FM women (mean age 49 years, range 25-63 years; American College of Rheumatology criteria) and ten healthy women matched for age were enrolled in the study. A voxel-by-voxel group analysis was performed using SPM2 (p<0.05, corrected for multiple comparisons). Visual Analogue Scale score for pain was 82+/-4 at the time of the SPECT study. RESULTS: Compared with control subjects, we observed individual brain SPECT abnormalities in FM patients, confirmed by SPM2 analysis, with hyperperfusion of the somatosensory cortex and hypoperfusion of the frontal, cingulate, medial temporal and cerebellar cortices. CONCLUSION: In the present study, performed without noxious stimuli in hyperalgesic FM patients, we found significant hyperperfusion in regions of the brain known to be involved in the sensory dimension of pain processing and significant hypoperfusion in areas assumed to be associated with the affective-attentional dimension. As current pharmacological and non-pharmacological therapies act differently on the two components of pain, we hypothesise that SPECT could be a valuable and readily available tool to guide individual therapeutic strategy and provide objective follow-up of pain processing recovery under treatment.
PURPOSE: Neuro-imaging studies with (99m)Tc-HMPAO SPECT in fibromyalgia (FM) patients have reported only limited subcortical hypoperfusion. (99m)Tc-ECD SPECT is known to provide better evaluation of areas of high cerebral blood flow and regional metabolic rate. We evaluated a homogeneous group of hyperalgesicpatients with FM using (99m)Tc-ECD SPECT. The aim of this study was to investigate brain processing associated with spontaneous pain in FM patients. METHODS: Eighteen hyperalgesic FMwomen (mean age 49 years, range 25-63 years; American College of Rheumatology criteria) and ten healthy women matched for age were enrolled in the study. A voxel-by-voxel group analysis was performed using SPM2 (p<0.05, corrected for multiple comparisons). Visual Analogue Scale score for pain was 82+/-4 at the time of the SPECT study. RESULTS: Compared with control subjects, we observed individual brain SPECT abnormalities in FM patients, confirmed by SPM2 analysis, with hyperperfusion of the somatosensory cortex and hypoperfusion of the frontal, cingulate, medial temporal and cerebellar cortices. CONCLUSION: In the present study, performed without noxious stimuli in hyperalgesic FMpatients, we found significant hyperperfusion in regions of the brain known to be involved in the sensory dimension of pain processing and significant hypoperfusion in areas assumed to be associated with the affective-attentional dimension. As current pharmacological and non-pharmacological therapies act differently on the two components of pain, we hypothesise that SPECT could be a valuable and readily available tool to guide individual therapeutic strategy and provide objective follow-up of pain processing recovery under treatment.
Authors: R Peyron; L García-Larrea; M C Grégoire; N Costes; P Convers; F Lavenne; F Mauguière; D Michel; B Laurent Journal: Brain Date: 1999-09 Impact factor: 13.501
Authors: J M Mountz; L A Bradley; J G Modell; R W Alexander; M Triana-Alexander; L A Aaron; K E Stewart; G S Alarcón; J D Mountz Journal: Arthritis Rheum Date: 1995-07
Authors: F Wolfe; H A Smythe; M B Yunus; R M Bennett; C Bombardier; D L Goldenberg; P Tugwell; S M Campbell; M Abeles; P Clark Journal: Arthritis Rheum Date: 1990-02
Authors: Sam T Donta; Daniel J Clauw; Charles C Engel; Peter Guarino; Peter Peduzzi; David A Williams; James S Skinner; André Barkhuizen; Thomas Taylor; Lewis E Kazis; Stephanie Sogg; Stephen C Hunt; Cynthia M Dougherty; Ralph D Richardson; Charles Kunkel; William Rodriguez; Edwin Alicea; Philippe Chiliade; Margaret Ryan; Gregory C Gray; Larry Lutwick; Dorothy Norwood; Samantha Smith; Michael Everson; Warren Blackburn; Wade Martin; J McLeod Griffiss; Robert Cooper; Ed Renner; James Schmitt; Cynthia McMurtry; Manisha Thakore; Deanna Mori; Robert Kerns; Maryann Park; Sally Pullman-Mooar; Jack Bernstein; Paul Hershberger; Don C Salisbury; John R Feussner Journal: JAMA Date: 2003-03-19 Impact factor: 56.272
Authors: M Signorini; E Paulesu; K Friston; D Perani; A Colleluori; G Lucignani; F Grassi; V Bettinardi; R S Frackowiak; F Fazio Journal: Neuroimage Date: 1999-01 Impact factor: 6.556
Authors: P Feraco; A Bacci; Fab Pedrabissi; L Passamonti; G Zampogna; Fed Pedrabissi; N Malavolta; M Leonardi Journal: AJNR Am J Neuroradiol Date: 2011-07-28 Impact factor: 3.825
Authors: B R Foerster; M Petrou; R E Harris; P B Barker; E G Hoeffner; D J Clauw; P C Sundgren Journal: AJNR Am J Neuroradiol Date: 2011-08-25 Impact factor: 3.825