Literature DB >> 21797334

Quasi-steady-state analysis of two-dimensional random intermittent search processes.

Paul C Bressloff1, Jay M Newby.   

Abstract

We use perturbation methods to analyze a two-dimensional random intermittent search process, in which a searcher alternates between a diffusive search phase and a ballistic movement phase whose velocity direction is random. A hidden target is introduced within a rectangular domain with reflecting boundaries. If the searcher moves within range of the target and is in the search phase, it has a chance of detecting the target. A quasi-steady-state analysis is applied to the corresponding Chapman-Kolmogorov equation. This generates a reduced Fokker-Planck description of the search process involving a nonzero drift term and an anisotropic diffusion tensor. In the case of a uniform direction distribution, for which there is zero drift, and isotropic diffusion, we use the method of matched asymptotics to compute the mean first passage time (MFPT) to the target, under the assumption that the detection range of the target is much smaller than the size of the domain. We show that an optimal search strategy exists, consistent with previous studies of intermittent search in a radially symmetric domain that were based on a decoupling or moment closure approximation. We also show how the decoupling approximation can break down in the case of biased search processes. Finally, we analyze the MFPT in the case of anisotropic diffusion and find that anisotropy can be useful when the searcher starts from a fixed location.

Entities:  

Year:  2011        PMID: 21797334     DOI: 10.1103/PhysRevE.83.061139

Source DB:  PubMed          Journal:  Phys Rev E Stat Nonlin Soft Matter Phys        ISSN: 1539-3755


  3 in total

1.  Model of Growth Cone Membrane Polarization via Microtubule Length Regulation.

Authors:  Bin Xu; Paul C Bressloff
Journal:  Biophys J       Date:  2015-11-17       Impact factor: 4.033

2.  Effective behavior of cooperative and nonidentical molecular motors.

Authors:  Joseph J Klobusicky; John Fricks; Peter R Kramer
Journal:  Res Math Sci       Date:  2020-09-21

3.  Renewal Reward Perspective on Linear Switching Diffusion Systems in Models of Intracellular Transport.

Authors:  Maria-Veronica Ciocanel; John Fricks; Peter R Kramer; Scott A McKinley
Journal:  Bull Math Biol       Date:  2020-09-16       Impact factor: 1.758

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.