Literature DB >> 21795043

The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth.

Stavroula K Hatzios1, Michael W Schelle, Gerald L Newton, Kimberly M Sogi, Cynthia M Holsclaw, Robert C Fahey, Carolyn R Bertozzi.   

Abstract

CysQ is a 3'-phosphoadenosine-5'-phosphatase that dephosphorylates intermediates from the sulfate assimilation pathway of Mycobacterium tuberculosis (Mtb). Here, we demonstrate that cysQ disruption attenuates Mtb growth in vitro and decreases the biosynthesis of sulfated glycolipids but not major thiols, suggesting that the encoded enzyme specifically regulates mycobacterial sulfation.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21795043      PMCID： PMC3184767          DOI： 10.1016/j.bmcl.2011.06.057

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  30 in total

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Journal:  Tubercle       Date:  1963-12

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3.  Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography.

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Journal:  Mol Cell       Date:  2000-04       Impact factor: 17.970

5.  Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman.

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6.  5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria.

Authors:  Spencer J Williams; Ryan H Senaratne; Joseph D Mougous; Lee W Riley; Carolyn R Bertozzi
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7.  New use of BCG for recombinant vaccines.

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8.  5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice.

Authors:  Ryan H Senaratne; A Dharshan De Silva; Spencer J Williams; Joseph D Mougous; J Rachel Reader; Tianjiao Zhang; Stephen Chan; Ben Sidders; Dong H Lee; John Chan; Carolyn R Bertozzi; Lee W Riley
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Review 9.  Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Authors:  Gerald L Newton; Nancy Buchmeier; Robert C Fahey
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056

10.  Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.

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  5 in total

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Authors:  Anna I Erickson; Reta D Sarsam; Andrew J Fisher
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-05-10       Impact factor: 1.056

3.  Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.

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4.  Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio).

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Journal:  PLoS One       Date:  2017-07-25       Impact factor: 3.240

5.  CysQ of Cryptosporidium parvum, a Protozoa, May Have Been Acquired from Bacteria by Horizontal Gene Transfer.

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  5 in total

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