PURPOSE: This study compares HRQOL among subgroups of infants with asthma-like symptoms to a subgroup without such symptoms and examines independent associations between asthma-like symptoms during the first year of life and HRQOL at age 12 months. METHODS: Our study sample included 5,000 infants participating in the Generation R study. Their parents completed structured questionnaires to obtain information on asthma-like symptoms, HRQOL, infants', and maternal characteristics. Asthma-like symptoms were defined according to the number of positive answers to 12 items on lower respiratory symptoms. HRQOL was measured using the ITQOL. Higher scores indicated better HRQOL. RESULTS: Infants with asthma-like symptoms had significantly lower HRQOL scores for all ITQOL scales. Among the subgroup with severe symptoms (4% of the infants), relevant deficits in HRQOL were observed for most ITQOL scales, particularly for General Health, Bodily Pain, and Family Activities (effect sizes ≥ 0.8). In multivariate linear models, asthma-like symptoms were independently associated with 6 ITQOL scales. The population attributable risks were especially high for Family Activities, General Health, Parental Emotional, and Parental Time. CONCLUSIONS: Asthma-like symptoms during the first year of life are associated with impaired quality of life at age 12 months. At population level, asthma-like symptoms were associated with lower HRQOL, regardless of symptom severity.
PURPOSE: This study compares HRQOL among subgroups of infants with asthma-like symptoms to a subgroup without such symptoms and examines independent associations between asthma-like symptoms during the first year of life and HRQOL at age 12 months. METHODS: Our study sample included 5,000 infants participating in the Generation R study. Their parents completed structured questionnaires to obtain information on asthma-like symptoms, HRQOL, infants', and maternal characteristics. Asthma-like symptoms were defined according to the number of positive answers to 12 items on lower respiratory symptoms. HRQOL was measured using the ITQOL. Higher scores indicated better HRQOL. RESULTS:Infants with asthma-like symptoms had significantly lower HRQOL scores for all ITQOL scales. Among the subgroup with severe symptoms (4% of the infants), relevant deficits in HRQOL were observed for most ITQOL scales, particularly for General Health, Bodily Pain, and Family Activities (effect sizes ≥ 0.8). In multivariate linear models, asthma-like symptoms were independently associated with 6 ITQOL scales. The population attributable risks were especially high for Family Activities, General Health, Parental Emotional, and Parental Time. CONCLUSIONS:Asthma-like symptoms during the first year of life are associated with impaired quality of life at age 12 months. At population level, asthma-like symptoms were associated with lower HRQOL, regardless of symptom severity.
Authors: B O Verburg; E A P Steegers; M De Ridder; R J M Snijders; E Smith; A Hofman; H A Moll; V W V Jaddoe; J C M Witteman Journal: Ultrasound Obstet Gynecol Date: 2008-04 Impact factor: 7.299
Authors: Bert Brunekreef; Jet Smit; Johan de Jongste; Herman Neijens; Jorrit Gerritsen; Dirkje Postma; Rob Aalberse; Laurens Koopman; Marjan Kerkhof; Alet Wilga; Rob van Strien Journal: Pediatr Allergy Immunol Date: 2002 Impact factor: 6.377
Authors: Andrea J Apter; Xingmei Wang; Daniel Bogen; Ian M Bennett; Rebecca M Jennings; Laura Garcia; Tamie Sharpe; Carmen Frazier; Thomas Ten Have Journal: Patient Educ Couns Date: 2009-02-13
Authors: Hein Raat; Jeanne M Landgraf; Rianne Oostenbrink; Henriëtte A Moll; Marie-Louise Essink-Bot Journal: Qual Life Res Date: 2006-11-17 Impact factor: 4.147
Authors: Vincent W V Jaddoe; Rachel Bakker; Cock M van Duijn; Albert J van der Heijden; Jan Lindemans; Johan P Mackenbach; Henriëtte A Moll; Eric A P Steegers; Henning Tiemeier; Andre G Uitterlinden; Frank C Verhulst; Albert Hofman Journal: Eur J Epidemiol Date: 2007-12-19 Impact factor: 8.082
Authors: Nicholas P Hays; Meng Mao; Lan Zhang; John Ge; Robert Northington; Manjiang Yao; Sheri Volger Journal: Health Qual Life Outcomes Date: 2016-08-08 Impact factor: 3.186