Literature DB >> 21790531

Imaging--the interface with pharmacology: looking to the future.

Andrew J Lawrence, Andreas Heinz.   

Abstract

Basic research is constantly adopting novel, innovative and powerful approaches to enable a deeper interrogation of the specific subject matter. A clear example of this strategy is the development of multiple imaging modalities, both in vitro and in vivo based, that have revolutionized medical research, drug discovery, diagnosis and clinical monitoring. In this themed section of the British Journal of Pharmacology, we highlight a number of imaging platforms which are discussed in relation to their applicability for pharmacological experiments, including longitudinal studies. As such, the authors endeavour to describe the technology, its limitations and how these approaches can complement pharmacological research. In addition, there is discussion of the role of pharmacological imaging from a clinical perspective.
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

Mesh:

Year:  2011        PMID: 21790531      PMCID: PMC3166687          DOI: 10.1111/j.1476-5381.2011.01294.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  15 in total

1.  Themed section: Imaging in pharmacology.

Authors:  Anthony P Davenport; Craig Daly
Journal:  Br J Pharmacol       Date:  2010-02       Impact factor: 8.739

Review 2.  Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks.

Authors:  Rachel H Rose; Stephen J Briddon; Nicholas D Holliday
Journal:  Br J Pharmacol       Date:  2009-12-10       Impact factor: 8.739

Review 3.  Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach.

Authors:  A R Finch; K R Sedgley; S P Armstrong; C J Caunt; C A McArdle
Journal:  Br J Pharmacol       Date:  2009-11-03       Impact factor: 8.739

4.  Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.

Authors:  Peter Johnström; Tim D Fryer; Hugh K Richards; Janet J Maguire; John C Clark; John D Pickard; Anthony P Davenport
Journal:  Br J Pharmacol       Date:  2010-02       Impact factor: 8.739

5.  Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.

Authors:  C J Daly; R A Ross; J Whyte; C M Henstridge; A J Irving; J C McGrath
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

6.  Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain.

Authors:  F Ortolano; P Maffia; G Dever; G Rodolico; O R Millington; M G De Simoni; J M Brewer; T J Bushell; P Garside; H V Carswell
Journal:  Br J Pharmacol       Date:  2009-12-10       Impact factor: 8.739

7.  The alpha 1B/D-adrenoceptor knockout mouse permits isolation of the vascular alpha 1A-adrenoceptor and elucidates its relationship to the other subtypes.

Authors:  L Methven; M McBride; G A Wallace; J C McGrath
Journal:  Br J Pharmacol       Date:  2009-06-30       Impact factor: 8.739

Review 8.  Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy.

Authors:  Patrick Baril; Pilar Martin-Duque; Georges Vassaux
Journal:  Br J Pharmacol       Date:  2009-10-08       Impact factor: 8.739

Review 9.  Signalling pathways underlying structural plasticity of dendritic spines.

Authors:  Michael Patterson; Ryohei Yasuda
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

10.  Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

Authors:  Jillian G Baker; Richard Middleton; Luke Adams; Lauren T May; Stephen J Briddon; Barrie Kellam; Stephen J Hill
Journal:  Br J Pharmacol       Date:  2010-01-26       Impact factor: 8.739

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