AIM/HYPOTHESIS: Diabetes and breast cancer are both serious life-threatening diseases across the world. Some studies shows that diabetes is associated with many kinds of tumor, but links with breast cancer remain controversial. The aim of this study was to assess the association the available evidence. SUBJECTS AND METHODS: A meta-analysis was conducted including 16 studies published between 2000 and 2010 and summary relative risks(RRs) with 95% CIs were calculated using random-effects model. RESULTS: The combined evidence supports that diabetes was associated with a statistically significant 23% increased risk of breast cancer, especially in postmenopausal women (RR=1.25 95%CI 1.20-1.29). The correlation between diabetes and breast cancer was the most obvious in Europe (RR=1.88,95%CI:1.56-2.25), followed by America (RR=1.16, 95%CI:1.12-1.20). In Asia the result was not significant (RR=1.01, 95%CI=0.84-1.21). Diabetes also increased mortality from breast cancer overall (RR=1.44, 95%CI:1.31-1.58). CONCLUSIONS/ INTERPRETATION: This meta-analysis indicated that diabetes can be considered as a risk factor for breast cancer. In addition, menstruation status as well as geographical distribution can affect the relationship.
AIM/HYPOTHESIS: Diabetes and breast cancer are both serious life-threatening diseases across the world. Some studies shows that diabetes is associated with many kinds of tumor, but links with breast cancer remain controversial. The aim of this study was to assess the association the available evidence. SUBJECTS AND METHODS: A meta-analysis was conducted including 16 studies published between 2000 and 2010 and summary relative risks(RRs) with 95% CIs were calculated using random-effects model. RESULTS: The combined evidence supports that diabetes was associated with a statistically significant 23% increased risk of breast cancer, especially in postmenopausal women (RR=1.25 95%CI 1.20-1.29). The correlation between diabetes and breast cancer was the most obvious in Europe (RR=1.88,95%CI:1.56-2.25), followed by America (RR=1.16, 95%CI:1.12-1.20). In Asia the result was not significant (RR=1.01, 95%CI=0.84-1.21). Diabetes also increased mortality from breast cancer overall (RR=1.44, 95%CI:1.31-1.58). CONCLUSIONS/ INTERPRETATION: This meta-analysis indicated that diabetes can be considered as a risk factor for breast cancer. In addition, menstruation status as well as geographical distribution can affect the relationship.
Authors: Gertraud Maskarinec; Simone Jacobs; Song-Yi Park; Christopher A Haiman; Veronica W Setiawan; Lynne R Wilkens; Loïc Le Marchand Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-01-13 Impact factor: 4.254
Authors: Juhua Luo; Beth Virnig; Michael Hendryx; Sijin Wen; Rowan Chelebowski; Chu Chen; Tomas Rohan; Lesley Tinker; Jean Wactawski-Wende; Lawrence Lessin; Karen Margolis Journal: Breast Cancer Res Treat Date: 2014-09-27 Impact factor: 4.872
Authors: K Sevcikova; Z Zhuang; G Garcia-Manero; R H Alvarez; H M Kantarjian; M Mego; C Albarracin; G Tang; S S Strom; L J Medeiros; G N Hortobagyi; J M Reuben; J D Khoury Journal: Leukemia Date: 2015-05-15 Impact factor: 11.528
Authors: Maureen Sanderson; Loren Lipworth; Martha J Shrubsole; Shaneda Warren Andersen; Xiao-Ou Shu; Wei Zheng; Margaret K Hargreaves; William J Blot Journal: Cancer Causes Control Date: 2019-04-02 Impact factor: 2.506
Authors: Gregory S Calip; Rebecca A Hubbard; Andy Stergachis; Kathleen E Malone; Julie R Gralow; Denise M Boudreau Journal: Pharmacoepidemiol Drug Saf Date: 2014-06-13 Impact factor: 2.890
Authors: Seungyoun Jung; Olga Goloubeva; Nola Hylton; Catherine Klifa; Erin LeBlanc; John Shepherd; Linda Snetselaar; Linda Van Horn; Joanne F Dorgan Journal: Cancer Causes Control Date: 2018-05-25 Impact factor: 2.506
Authors: T Kwak; K Drews-Elger; A Ergonul; P C Miller; A Braley; G H Hwang; D Zhao; A Besser; Y Yamamoto; H Yamamoto; D El-Ashry; J M Slingerland; M E Lippman; B I Hudson Journal: Oncogene Date: 2016-09-26 Impact factor: 9.867
Authors: Maureen Sanderson; Jay H Fowke; Loren Lipworth; Xijing Han; Flora Ukoli; Ann L Coker; William J Blot; Margaret K Hargreaves Journal: Cancer Causes Control Date: 2013-07-17 Impact factor: 2.506