Literature DB >> 21787322

Alzheimer's disease genetics: lessons to improve disease modelling.

Rita J Guerreiro1, John Hardy.   

Abstract

In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.

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Year:  2011        PMID： 21787322     DOI： 10.1042/BST0390910

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  15 in total

Review 1.  Genetic architectures of psychiatric disorders: the emerging picture and its implications.

Authors:  Patrick F Sullivan; Mark J Daly; Michael O'Donovan
Journal:  Nat Rev Genet       Date:  2012-07-10       Impact factor: 53.242

2.  FoxO6 regulates memory consolidation and synaptic function.

Authors:  Dervis A M Salih; Asim J Rashid; Damien Colas; Luis de la Torre-Ubieta; Ruo P Zhu; Alexander A Morgan; Evan E Santo; Duygu Ucar; Keerthana Devarajan; Christina J Cole; Daniel V Madison; Mehrdad Shamloo; Atul J Butte; Azad Bonni; Sheena A Josselyn; Anne Brunet
Journal:  Genes Dev       Date:  2012-12-07       Impact factor: 11.361

3.  Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Authors:  Burcu F Darst; Rebecca L Koscik; Annie M Racine; Jennifer M Oh; Rachel A Krause; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Bradley T Christian; Barbara B Bendlin; Ozioma C Okonkwo; Kirk J Hogan; Bruce P Hermann; Mark A Sager; Sanjay Asthana; Sterling C Johnson; Corinne D Engelman
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

Review 4.  Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction.

Authors:  Leo Ungar; Andre Altmann; Michael D Greicius
Journal:  Brain Imaging Behav       Date:  2014-06       Impact factor: 3.978

5.  β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

Authors:  Wayne W Poon; Anthony J Carlos; Brittany L Aguilar; Nicole C Berchtold; Crystal K Kawano; Vahe Zograbyan; Tim Yaopruke; Michael Shelanski; Carl W Cotman
Journal:  J Biol Chem       Date:  2013-04-18       Impact factor: 5.157

Review 6.  Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Authors:  Jessica E Young; Lawrence S B Goldstein
Journal:  Hum Mol Genet       Date:  2012-08-02       Impact factor: 6.150

Review 7.  The paradox of syndromic diversity in Alzheimer disease.

Authors:  Jason D Warren; Phillip D Fletcher; Hannah L Golden
Journal:  Nat Rev Neurol       Date:  2012-07-17       Impact factor: 42.937

8.  An early and late peak in microglial activation in Alzheimer's disease trajectory.

Authors:  Zhen Fan; David J Brooks; Aren Okello; Paul Edison
Journal:  Brain       Date:  2017-03-01       Impact factor: 13.501

9.  Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.

Authors:  Patrick Holton; Mina Ryten; Michael Nalls; Daniah Trabzuni; Michael E Weale; Dena Hernandez; Helen Crehan; J Raphael Gibbs; Richard Mayeux; Jonathan L Haines; Lindsay A Farrer; Margaret A Pericak-Vance; Gerard D Schellenberg; Manuel Ramirez-Restrepo; Anzhelika Engel; Amanda J Myers; Jason J Corneveaux; Matthew J Huentelman; Allissa Dillman; Mark R Cookson; Eric M Reiman; Andrew Singleton; John Hardy; Rita Guerreiro
Journal:  Ann Hum Genet       Date:  2013-01-30       Impact factor: 1.670

Review 10.  Stem cell models of Alzheimer's disease and related neurological disorders.

Authors:  Frederick J Livesey
Journal:  Alzheimers Res Ther       Date:  2012-11-06       Impact factor: 6.982
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