Literature DB >> 21783860

CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs.

Sisir K Dutta1, Somiranjan Ghosh, Supriyo De, Eric P Hoffman.   

Abstract

We have identified two most significant biomarker genes, CYP1A1 (69.81 up-regulation) and MT1K (14.66 up-regulation), showing highest overexpression at p-value <0.005. These were selected out of several hundred genes induced in vitro, using PCB exposed human liver (HepG2) cells. Over expression of the CYP1A1 (cytochrome P450) gene was specific to PCB-77 and MT1K (Metallothionein) to PCB-153. Affymetrix oligonucleotide microarrays (mRNA) were used to screen the entire genome of human liver cells in a time-dependent exposure and were further validated by quantitative real-time RT-PCR.
Copyright © 2007. Published by Elsevier B.V.

Entities:  

Year:  2007        PMID： 21783860     DOI： 10.1016/j.etap.2007.10.018

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  10 in total

1.  Polychlorinated biphenyls (PCB-153) and (PCB-77) absorption in human liver (HepG2) and kidney (HK2) cells in vitro: PCB levels and cell death.

Authors:  Somiranjan Ghosh; Supriyo De; Yongqing Chen; Darryl C Sutton; Folahan O Ayorinde; Sisir K Dutta
Journal:  Environ Int       Date:  2010-08-17       Impact factor: 9.621

2.  Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: indicator of disease and disorder development in humans.

Authors:  Somiranjan Ghosh; Partha S Mitra; Christopher A Loffredo; Tomas Trnovec; Lubica Murinova; Eva Sovcikova; Svetlana Ghimbovschi; Shizhu Zang; Eric P Hoffman; Sisir K Dutta
Journal:  Environ Res       Date:  2015-02-27       Impact factor: 6.498

Review 3.  Biomarkers linking PCB exposure and obesity.

Authors:  Somiranjan Ghosh; Lubica Murinova; Tomas Trnovec; Christopher A Loffredo; Kareem Washington; Partha S Mitra; Sisir K Dutta
Journal:  Curr Pharm Biotechnol       Date:  2014       Impact factor: 2.837

4.  PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations.

Authors:  Somiranjan Ghosh; Christopher A Loffredo; Partha S Mitra; Tomas Trnovec; Lubica Palkovicova Murinova; Eva Sovcikova; Eric P Hoffman; Kepher H Makambi; Sisir K Dutta
Journal:  Environ Sci Pollut Res Int       Date:  2017-11-15       Impact factor: 4.223

5.  Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk.

Authors:  Partha Sarathi Mitra; Somiranjan Ghosh; Shizhu Zang; Dean Sonneborn; Irva Hertz-Picciotto; Tomas Trnovec; Lubica Palkovicova; Eva Sovcikova; Svetlana Ghimbovschi; Eric P Hoffman; Sisir K Dutta
Journal:  Environ Int       Date:  2011-12-08       Impact factor: 9.621

6.  Differential gene expression and a functional analysis of PCB-exposed children: understanding disease and disorder development.

Authors:  Sisir K Dutta; Partha S Mitra; Somiranjan Ghosh; Shizhu Zang; Dean Sonneborn; Irva Hertz-Picciotto; Tomas Trnovec; Lubica Palkovicova; Eva Sovcikova; Svetlana Ghimbovschi; Eric P Hoffman
Journal:  Environ Int       Date:  2011-09-08       Impact factor: 9.621

7.  Status of LEPR Gene in PCB-exposed Population: A Quick Look.

Authors:  Somiranjan Ghosh; Tomas Trnovec; Lubica Palkovicova; Eric P Hoffman; Kareem Washington; Sisir K Dutta
Journal:  Int J Hum Genet       Date:  2013-03       Impact factor: 0.226

8.  Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities.

Authors:  Somiranjan Ghosh; Shizhu Zang; Partha S Mitra; Svetlana Ghimbovschi; Eric P Hoffman; Sisir K Dutta
Journal:  Environ Int       Date:  2011-04-05       Impact factor: 9.621

9.  Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells.

Authors:  Marike M Leijs; Lin Gan; Patrick De Boever; André Esser; Philipp M Amann; Patrick Ziegler; Katharina Fietkau; Thomas Schettgen; Thomas Kraus; Hans F Merk; Jens M Baron
Journal:  Int J Environ Res Public Health       Date:  2019-06-13       Impact factor: 3.390

10.  Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators.

Authors:  Randa M Breikaa; Mardi M Algandaby; Ebtehal El-Demerdash; Ashraf B Abdel-Naim
Journal:  PLoS One       Date:  2013-07-16       Impact factor: 3.240
  10 in total

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