BACKGROUND: Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by dematiaceous fungi. METHODS: We described epidemiological data, clinical presentation, and treatment of 18 cases of CBM diagnosed in Rio de Janeiro, Brazil. Diagnosis was obtained by mycological, histopathological findings demonstrating typical muriform cells with confirmation of isolated by DNA sequencing of the ribosomal internal transcribed spacer. RESULTS: The majority of patients were male (72.2%) ranging from 39 to 83 years old, farm laborers and construction workers. The duration of disease varied from four months to 32 years. The most common presentations were verrucous form in ten (55.6%) patients, followed by tumoral in three (16.7%) patients, primarily of moderate (55.6%) and severe (38.9%) intensity. Lower (44.4%) and upper limbs (33.3%) were the most affected sites. Fonsecaea pedrosoi isolated from 14 (77.8%), and Cladophialophora carrionii isolated from one case (5.6%). Fifteen patients (83.3%) were treated. Six patients (40%) received oral itraconazole 200-400 mg/day, five patients (33.3%) received oral itraconazole 200-400 mg/day combined with fluconazole 200 mg/day, and four (26.7%) patients were submitted to surgery. The duration of therapy varied from 12 to 48 months. Cure rate was 80% (12/15). No relapse was observed after two years of follow-up. CONCLUSIONS: Success was due to attending a center with specialized clinical care, laboratory support, and pharmaceutical care.
BACKGROUND:Chromoblastomycosis (CBM) is a chronic subcutaneous mycosis caused by dematiaceous fungi. METHODS: We described epidemiological data, clinical presentation, and treatment of 18 cases of CBM diagnosed in Rio de Janeiro, Brazil. Diagnosis was obtained by mycological, histopathological findings demonstrating typical muriform cells with confirmation of isolated by DNA sequencing of the ribosomal internal transcribed spacer. RESULTS: The majority of patients were male (72.2%) ranging from 39 to 83 years old, farm laborers and construction workers. The duration of disease varied from four months to 32 years. The most common presentations were verrucous form in ten (55.6%) patients, followed by tumoral in three (16.7%) patients, primarily of moderate (55.6%) and severe (38.9%) intensity. Lower (44.4%) and upper limbs (33.3%) were the most affected sites. Fonsecaea pedrosoi isolated from 14 (77.8%), and Cladophialophora carrionii isolated from one case (5.6%). Fifteen patients (83.3%) were treated. Six patients (40%) received oral itraconazole 200-400 mg/day, five patients (33.3%) received oral itraconazole 200-400 mg/day combined with fluconazole 200 mg/day, and four (26.7%) patients were submitted to surgery. The duration of therapy varied from 12 to 48 months. Cure rate was 80% (12/15). No relapse was observed after two years of follow-up. CONCLUSIONS: Success was due to attending a center with specialized clinical care, laboratory support, and pharmaceutical care.
Authors: Gabriela X Schneider; Renata R Gomes; Amanda Bombassaro; Kassiely Zamarchi; Morgana F Voidaleski; Flávia F Costa; Aniele C R Leão; Bruna J F S Lima; Bruna S Soley; Israella R Colombo; Giovanna Z Cândido; Mohammad J Najafzadeh; Jiufeng Sun; Conceição M P S de Azevedo; Sirlei G Marques; G Sybren de Hoog; Vânia A Vicente Journal: Mycopathologia Date: 2019-07-17 Impact factor: 2.574
Authors: Felipe Maurício Soeiro Sampaio; Maria Clara Gutierrez Galhardo; Leonardo Pereira Quintella; Paulo Roberto Cotrim de Souza; Janice Mary Chicarino de Oliveira Coelho; Antonio Carlos Francesconi do Valle Journal: An Bras Dermatol Date: 2013 Nov-Dec Impact factor: 1.896
Authors: Felipe Maurício Soeiro Sampaio; Bodo Wanke; Dayvison Francis Saraiva Freitas; Janice Mery Chicarino de Oliveira Coelho; Maria Clara Gutierrez Galhardo; Marcelo Rosandiski Lyra; Maria Cristina da Silva Lourenço; Rodrigo de Almeida Paes; Antonio Carlos Francesconi do Valle Journal: PLoS Negl Trop Dis Date: 2017-02-13
Authors: Rowena Alves Coelho; Fábio Brito-Santos; Maria Helena Galdino Figueiredo-Carvalho; Juliana Vitoria Dos Santos Silva; Maria Clara Gutierrez-Galhardo; Antonio Carlos Francesconi do Valle; Rosely Maria Zancopé-Oliveira; Luciana Trilles; Wieland Meyer; Dayvison Francis Saraiva Freitas; Rodrigo Almeida-Paes Journal: PLoS Negl Trop Dis Date: 2018-07-26