| Literature DB >> 21778056 |
William J McClellan1, Yujia Dai, Cele Abad-Zapatero, Daniel H Albert, Jennifer J Bouska, Keith B Glaser, Terry J Magoc, Patrick A Marcotte, Donald J Osterling, Kent D Stewart, Steven K Davidsen, Michael R Michaelides.
Abstract
In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine residue with a thienopyrimidine moiety led to a series of potent and selective Aurora inhibitors.Entities:
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Year: 2011 PMID： 21778056 DOI： 10.1016/j.bmcl.2011.06.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823