| Literature DB >> 21773906 |
Tetsuro Ohno1, Kyoichi Ogata, Norimichi Kogure, Hiroyuki Ando, Ryuusuke Aihara, Erito Mochiki, Hiroaki Zai, Akihiko Sano, Toshihide Kato, Shinji Sakurai, Tetsunari Oyama, Takayuki Asao, Hiroyuki Kuwano.
Abstract
Schwannomas are tumors originating from any nerve that has a Schwann cell sheath. Gastrointestinal (GI) schwannomas represent only 3% of all GI mesenchymal tumors. The stomach is the most common site of GI schwannomas, and schwannomas account for 0.2% of all gastric neoplasms. This report presents two cases of gastric schwannomas showing increased [18F]fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET; maximum standardized uptake value 7.10 and 6.05). Additional immunohistochemical staining of glucose transporter type 1 (GLUT1) and the autocrine motility factor (AMF) was conducted after the tumors were resected, to identify the mechanism that increased FDG uptake on PET. Immunohistochemical expression of AMF was positive in both cases, whereas GLUT1 was negative. Autocrine motility factor is also known as phosphoglucose isomerase. However, the mechanism by which FDG is accumulated in schwannoma cells is uncertain, and may be related to intracellular glycolytic activity.Entities:
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Year: 2011 PMID： 21773906 DOI： 10.1007/s00595-010-4401-2
Source DB: PubMed Journal: Surg Today ISSN： 0941-1291 Impact factor: 2.549