BACKGROUND: Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). AIM: To describe diagnostic stability and the variables related to diagnostic changes. METHODS: Participants were 83 patients (aged 9-17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. RESULTS: The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children's Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss-Carpenter Outcome Scale. CONCLUSIONS: Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached.
BACKGROUND: Only one study has used a prospective method to analyze the diagnostic stability of first psychotic episodes in children and adolescents. The Child and Adolescent First-Episode Psychosis Study (CAFEPS) is a 2-year, prospective longitudinal study of early-onset first episodes of psychosis (EO-FEP). AIM: To describe diagnostic stability and the variables related to diagnostic changes. METHODS:Participants were 83 patients (aged 9-17 years) with an EO-FEP consecutively attended. They were assessed with a structured interview (Kiddie-Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version) and clinical scales at baseline and after 2 years. RESULTS: The global consistency for all diagnoses was 63.9%. The small group of bipolar disorder had high stability (92.31%) as did the group with schizophrenia spectrum disorders (90.00%). Depressive disorder had lower stability (37.50%) and the lowest values were for psychotic disorder not otherwise specified (11.76%) and brief psychotic disorder (0%).The most frequent diagnostic shift was to schizophrenia spectrum and bipolar disorders. One group of patients did not meet the criteria for any diagnosis at follow-up. Independent predictors of change to schizophrenia spectrum disorders were lower scores on the Children's Global Assessment Scale (CGAS) and the Hamilton Depression Rating Scale. Predictors of not having a diagnosis at follow-up were the CGAS and the Strauss-Carpenter Outcome Scale. CONCLUSIONS: Global diagnostic stability was 63.9%. Bipolar and schizophrenia spectrum disorders were the most stable diagnoses, while depressive disorder and other psychosis the least stable. Psychosocial functioning at baseline was a good predictor of diagnosis at follow-up. These data show the need for longitudinal follow-up in EO-FEP before a stable diagnosis is reached.
Authors: Ángel Del Rey-Mejías; David Fraguas; Covadonga M Díaz-Caneja; Laura Pina-Camacho; Josefina Castro-Fornieles; Inmaculada Baeza; Ana Espliego; Jessica Merchán-Naranjo; Ana González-Pinto; Elena de la Serna; Beatriz Payá; Montserrat Graell; Celso Arango; Mara Parellada Journal: Eur Child Adolesc Psychiatry Date: 2015-03-01 Impact factor: 4.785
Authors: Anne Marie Greenhalgh; Leticia Gonzalez-Blanco; Clemente Garcia-Rizo; Emilio Fernandez-Egea; Brian Miller; Miguel Bernardo Arroyo; Brian Kirkpatrick Journal: Schizophr Res Date: 2016-10-17 Impact factor: 4.939
Authors: Laura Pina-Camacho; Juan Garcia-Prieto; Mara Parellada; Josefina Castro-Fornieles; Ana M Gonzalez-Pinto; Igor Bombin; Montserrat Graell; Beatriz Paya; Marta Rapado-Castro; Joost Janssen; Inmaculada Baeza; Francisco Del Pozo; Manuel Desco; Celso Arango Journal: Eur Child Adolesc Psychiatry Date: 2014-08-11 Impact factor: 4.785
Authors: Ditte Lammers Vernal; Anne Dorte Stenstrøm; Nina Staal; Anne Marie Raabjerg Christensen; Christine Ebbesen; Anne Katrine Pagsberg; Christoph U Correll; René Ernst Nielsen; Marlene Briciet Lauritsen Journal: Eur Child Adolesc Psychiatry Date: 2018-01-03 Impact factor: 4.785
Authors: Laura Pina-Camacho; Ángel Del Rey-Mejías; Joost Janssen; Miquel Bioque; Ana González-Pinto; Celso Arango; Antonio Lobo; Salvador Sarró; Manuel Desco; Julio Sanjuan; Maria Lacalle-Aurioles; Manuel J Cuesta; Jerónimo Saiz-Ruiz; Miguel Bernardo; Mara Parellada Journal: Schizophr Bull Date: 2015-09-14 Impact factor: 9.306
Authors: Ditte L Vernal; Sandeep Kapoor; Aseel Al-Jadiri; Eva M Sheridan; Yehonathan Borenstein; Charles Mormando; Lisa David; Sukhbir Singh; Andrew J Seidman; Maren Carbon; Miriam Gerstenberg; Ema Saito; John M Kane; Hans-Christoph Steinhausen; Christoph U Correll Journal: J Child Adolesc Psychopharmacol Date: 2015-09 Impact factor: 2.576
Authors: Covadonga M Díaz-Caneja; Laura Pina-Camacho; Alberto Rodríguez-Quiroga; David Fraguas; Mara Parellada; Celso Arango Journal: NPJ Schizophr Date: 2015-03-04