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Literature DB >> 2176588

Mechanism of action of organophosphorus and carbamate insecticides.

Abstract

Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed.

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 2176588 PMCID： PMC1567830 DOI： 10.1289/ehp.9087245

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

11 in total

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Authors: I B WILSON; M A HATCH; S GINSBURG
Journal: J Biol Chem Date: 1960-08 Impact factor: 5.157

2. A cholinesterase inhibitor derived from OO-diethyl O-p-nitrophenyl thiophosphate in vivo.

Authors: J C GAGE
Journal: Biochem J Date: 1953-06 Impact factor: 3.857

3. The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. I. Diethyl p nitrophenyl phosphate (E600) and analogues.

Authors: W N ALDRIDGE; A N DAVISON
Journal: Biochem J Date: 1952-04 Impact factor: 3.857

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Authors: W N ALDRIDGE
Journal: Biochem J Date: 1950-04 Impact factor: 3.857

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Authors: P Ott
Journal: Biochim Biophys Acta Date: 1985-12-09

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Authors: J Massoulié; S Bon
Journal: Annu Rev Neurosci Date: 1982 Impact factor: 12.449

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Authors: A L Gnagey; M Forte; T L Rosenberry
Journal: J Biol Chem Date: 1987-09-25 Impact factor: 5.157

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Authors: C Hansch; E W Deutsch
Journal: Biochim Biophys Acta Date: 1966-09-05

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Authors: R L Metcalf
Journal: Bull World Health Organ Date: 1971 Impact factor: 9.408

10. AFFINITY AND PHOSPHORYLATION CONSTANTS FOR THE INHIBITION OF ESTERASES BY ORGANOPHOSPHATES.

Authors: A R MAIN
Journal: Science Date: 1964-05-22 Impact factor: 47.728

141 in total

1. Organ-specific ATPase and phosphorylase enzyme activities in a food fish exposed to a carbamate insecticide and recovery response.

Authors: Ghousia Begum
Journal: Fish Physiol Biochem Date: 2010-07-11 Impact factor: 2.794

Review 2. Targeting renal epithelial channels for the control of insect vectors.

Authors: Klaus W Beyenbach; Yasong Yu; Peter M Piermarini; Jerod Denton
Journal: Tissue Barriers Date: 2015-09-01

3. Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase.

Authors: Fan Tong; Rafique M Islam; Paul R Carlier; Ming Ma; Fredrik Ekström; Jeffrey R Bloomquist
Journal: Pestic Biochem Physiol Date: 2013-07-01 Impact factor: 3.963

4. Hematological and gill histopathological changes in iridescent shark, Pangasius hypophthalmus (Sauvage, 1878) exposed to sublethal diazinon and deltamethrin concentrations.

Authors: Aliakbar Hedayati; Reza Tarkhani
Journal: Fish Physiol Biochem Date: 2013-10-15 Impact factor: 2.794

Review 5. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights.

Authors: Caio R D Assis; Amanda G Linhares; Mariana P Cabrera; Vagne M Oliveira; Kaline C C Silva; Marina Marcuschi; Elba V M Maciel Carvalho; Ranilson S Bezerra; Luiz B Carvalho
Journal: Environ Sci Pollut Res Int Date: 2018-05-24 Impact factor: 4.223

6. A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs.

Authors: Sehan Lee; Mace G Barron
Journal: J Comput Aided Mol Des Date: 2016-04-07 Impact factor: 3.686

7. Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine.

Authors: Amit Kamboj; Ravi Kiran; Rajat Sandhir
Journal: Exp Brain Res Date: 2005-11-24 Impact factor: 1.972

8. Avoidance behaviour response and esterase inhibition in the earthworm, Lumbricus terrestris, after exposure to chlorpyrifos.

Authors: S Martínez Morcillo; J L Yela; Y Capowiez; C Mazzia; M Rault; Juan C Sanchez-Hernandez
Journal: Ecotoxicology Date: 2013-02-24 Impact factor: 2.823

9. Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures.

Authors: Feng Yi; Evan DeCan; Kurt Stoll; Eric Marceau; Karl Deisseroth; J Josh Lawrence
Journal: Epilepsia Date: 2014-12-13 Impact factor: 5.864

10. Mitochondrial oxidative stress and dysfunction in rat brain induced by carbofuran exposure.

Authors: Sukhdev Singh Kamboj; Vikas Kumar; Amit Kamboj; Rajat Sandhir
Journal: Cell Mol Neurobiol Date: 2008-03-14 Impact factor: 5.046