Literature DB >> 14137949

AFFINITY AND PHOSPHORYLATION CONSTANTS FOR THE INHIBITION OF ESTERASES BY ORGANOPHOSPHATES.

A R MAIN.   

Abstract

Equations based on the assumption of a reversible first step in the reaction between organophosphate inhibitors and esterases are proposed for the bimolecular rate constant which now includes an affinity constant and a phosphorylation constant. The treatment applies when the inhibition reaction follows first-order kinetics.

Entities:  

Keywords:  CHEMISTRY; CHOLINESTERASE; ENZYME INHIBITORS; ESTERASES; EXPERIMENTAL LAB STUDY; ISOFLUROPHATE; PHOSPHORUS POISONS, ORGANIC

Mesh：

Substances：

Year:  1964        PMID： 14137949     DOI： 10.1126/science.144.3621.992

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  On the mechanism of anticholinesterase action of organophosphorous quasi-substrates.

Authors:  E V Rozengart
Journal:  Dokl Biochem Biophys       Date:  2001 May-Jun       Impact factor: 0.788

2.  Rat brain acetylcholinesterase response to monocrotophos and abate.

Authors:  J V Rao; A N Swamy; S Yamin
Journal:  Bull Environ Contam Toxicol       Date:  1992-06       Impact factor: 2.151

3.  A comparison of acylation, phosphorylation and binding in related substrates and inhibitors of serum cholinesterase.

Authors:  A R Main; F L Hastings
Journal:  Biochem J       Date:  1966-12       Impact factor: 3.857

4.  Calculation of a safe reentry time into an orchard treated with a pesticide chemical which produces a measurable physiological response.

Authors:  W F Serat
Journal:  Arch Environ Contam Toxicol       Date:  1973-07       Impact factor: 2.804

5.  Inhibition of brain cholinesterase activity after the injection of organophosphorus compounds in the rat.

Authors:  B Reiff
Journal:  Br J Pharmacol       Date:  1970-09       Impact factor: 8.739

6.  Binding sites of cholinesterases. Alkylation by an aziridinium derivative.

Authors:  R D O'Brien
Journal:  Biochem J       Date:  1969-07       Impact factor: 3.857

7.  Effect of temperature and pH on carbamoylation and phosphorylation of serum cholinesterases. Theoretical interpretation of activation energies in complex reactions.

Authors:  V Simeon; E Reiner; C A Vernon
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

8.  Inhibition of fly head acetylcholinesterase by bis-[(m-hydroxyphenyl)-trimethylammonium iodide] esters of polymethylenedicarbamic acids.

Authors:  J H Davies; W R Campbell; C W Kearns
Journal:  Biochem J       Date:  1970-04       Impact factor: 3.857

9.  Interpretation of the mechanism of acetylcholinesterase inhibition ability by organophosphorus compounds through a new conformational descriptor. an experimental and theoretical study.

Authors:  Guido Mastrantonio; Hans-Georg Mack; Carlos Omar Della Védova
Journal:  J Mol Model       Date:  2008-06-26       Impact factor: 1.810

10.  An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon.

Authors:  Josephine Shenouda; Paula Green; Lester Sultatos
Journal:  Toxicol Appl Pharmacol       Date:  2009-08-19       Impact factor: 4.219
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.