Literature DB >> 21765557

A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.

Yangmei Li1, Marc Giulianotti, Richard A Houghten.   

Abstract

A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a "volatilizable" support. The products were cleaved with 10% HF and were obtained in high yields and purities.

Entities:  

Year:  2010        PMID： 21765557      PMCID： PMC3133972          DOI： 10.1016/j.tetlet.2010.08.026

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  21 in total

1.  "Volatilizable" supports for high-throughput organic synthesis.

Authors:  Richard A Houghten; Yongping Yu
Journal:  J Am Chem Soc       Date:  2005-06-22       Impact factor: 15.419

2.  Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones.

Authors:  Paola Vicini; Athina Geronikaki; Kitka Anastasia; Matteo Incerti; Franca Zani
Journal:  Bioorg Med Chem       Date:  2006-02-20       Impact factor: 3.641

3.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

4.  2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.

Authors:  Mahendra D Chordia; Lauren J Murphree; Timothy L Macdonald; Joel Linden; Ray A Olsson
Journal:  Bioorg Med Chem Lett       Date:  2002-06-17       Impact factor: 2.823

5.  Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

Authors:  H M Geysen; R H Meloen; S J Barteling
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

6.  Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor.

Authors:  B Latli; K D'Amour; J E Casida
Journal:  J Med Chem       Date:  1999-06-17       Impact factor: 7.446

7.  A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

Authors:  P G Komarov; E A Komarova; R V Kondratov; K Christov-Tselkov; J S Coon; M V Chernov; A V Gudkov
Journal:  Science       Date:  1999-09-10       Impact factor: 47.728

8.  2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.

Authors:  Jagabandhu Das; Ping Chen; Derek Norris; Ramesh Padmanabha; James Lin; Robert V Moquin; Zhongqi Shen; Lynda S Cook; Arthur M Doweyko; Sidney Pitt; Suhong Pang; Ding Ren Shen; Qiong Fang; Henry F de Fex; Kim W McIntyre; David J Shuster; Kathleen M Gillooly; Kamelia Behnia; Gary L Schieven; John Wityak; Joel C Barrish
Journal:  J Med Chem       Date:  2006-11-16       Impact factor: 7.446

9.  N-(4-substituted-thiazolyl)oxamic acid derivatives, a new series of potent, orally active antiallergy agents.

Authors:  K D Hargrave; F K Hess; J T Oliver
Journal:  J Med Chem       Date:  1983-08       Impact factor: 7.446

10.  Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.

Authors:  John L Kane; Bradford H Hirth; Beirong Liang; Brian B Gourlie; Sharon Nahill; Gary Barsomian
Journal:  Bioorg Med Chem Lett       Date:  2003-12-15       Impact factor: 2.823
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