OBJECTIVE: Micro-computed tomography is used frequently in preclinical in vivo research. Limiting factors are radiation dose and long scan times. The purpose of the study was to compare a standard step-and-shoot to a continuous-rotation, high-speed scanning protocol. METHODS: Micro-computed tomography of a lead grid phantom and a rat femur was performed using a step-and-shoot and a continuous-rotation protocol. Detail discriminability and image quality were assessed by 3 radiologists. The signal-to-noise ratio and the modulation transfer function were calculated, and volumetric analyses of the femur were performed. The radiation dose of the scan protocols was measured using thermoluminescence dosimeters. RESULTS: The 40-second continuous-rotation protocol allowed a detail discriminability comparable to the step-and-shoot protocol at significantly lower radiation doses. No marked differences in volumetric or qualitative analyses were observed. CONCLUSIONS: Continuous-rotation micro-computed tomography significantly reduces scanning time and radiation dose without relevantly reducing image quality compared with a normal step-and-shoot protocol.
OBJECTIVE: Micro-computed tomography is used frequently in preclinical in vivo research. Limiting factors are radiation dose and long scan times. The purpose of the study was to compare a standard step-and-shoot to a continuous-rotation, high-speed scanning protocol. METHODS: Micro-computed tomography of a lead grid phantom and a rat femur was performed using a step-and-shoot and a continuous-rotation protocol. Detail discriminability and image quality were assessed by 3 radiologists. The signal-to-noise ratio and the modulation transfer function were calculated, and volumetric analyses of the femur were performed. The radiation dose of the scan protocols was measured using thermoluminescence dosimeters. RESULTS: The 40-second continuous-rotation protocol allowed a detail discriminability comparable to the step-and-shoot protocol at significantly lower radiation doses. No marked differences in volumetric or qualitative analyses were observed. CONCLUSIONS:Continuous-rotation micro-computed tomography significantly reduces scanning time and radiation dose without relevantly reducing image quality compared with a normal step-and-shoot protocol.
Authors: Andreas Keuler; Christian Taschner; Marc Alexander Brockmann; Hanne Boll; Katharina Förster; Lisa Lutz; Annegret Herrmann-Frank; Monika Lelgemann; Martin Schumacher Journal: Neuroradiology Date: 2014-01-31 Impact factor: 2.804
Authors: Hanne Boll; Stefanie Nittka; Fabian Doyon; Michael Neumaier; Alexander Marx; Martin Kramer; Christoph Groden; Marc A Brockmann Journal: PLoS One Date: 2011-09-30 Impact factor: 3.240
Authors: Axel Neulen; Tobias Pantel; Michael Kosterhon; Stefanie Kirschner; Marc A Brockmann; Sven R Kantelhardt; Alf Giese; Serge C Thal Journal: PLoS One Date: 2017-02-15 Impact factor: 3.240