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Literature DB >> 21763616

Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.

Vicki P Losick¹, Lucy X Morris, Donald T Fox, Allan Spradling.

Abstract

The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

Entities: Chemical

Mesh：

Year: 2011 PMID： 21763616 PMCID： PMC6894370 DOI： 10.1016/j.devcel.2011.06.018

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

144 in total

1. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development.

Authors: Dong Yan; Yihui Wu; Yongfei Yang; Tatyana Y Belenkaya; Xiaofang Tang; Xinhua Lin
Journal: Development Date: 2010-06 Impact factor: 6.868

Review 2. Intestinal stem cells in mammals and Drosophila.

Authors: Andreu Casali; Eduard Batlle
Journal: Cell Stem Cell Date: 2009-02-06 Impact factor: 24.633

3. Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis.

Authors: Monica Boyle; Chihunt Wong; Michael Rocha; D Leanne Jones
Journal: Cell Stem Cell Date: 2007-10-11 Impact factor: 24.633

4. The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3.

Authors: Hitomi Suzuki; Aiko Sada; Shosei Yoshida; Yumiko Saga
Journal: Dev Biol Date: 2009-10-08 Impact factor: 3.582

5. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila.

Authors: S L Page; K S McKim; B Deneen; T L Van Hook; R S Hawley
Journal: Genetics Date: 2000-08 Impact factor: 4.562

6. Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway.

Authors: Shigeo Takashima; Katrina L Adams; Paola A Ortiz; Chong T Ying; Rameen Moridzadeh; Amelia Younossi-Hartenstein; Volker Hartenstein
Journal: Dev Biol Date: 2011-03-05 Impact factor: 3.582

7. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells.

Authors: Zhu A Wang; Daniel Kalderon
Journal: Proc Natl Acad Sci U S A Date: 2009-12-04 Impact factor: 11.205

8. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary.

Authors: Lourdes López-Onieva; Ana Fernández-Miñán; Acaimo González-Reyes
Journal: Development Date: 2008-01-02 Impact factor: 6.868

Review 9. Germ cell sex determination: a collaboration between soma and germline.

Authors: Sheryl M Murray; Shu Yuan Yang; Mark Van Doren
Journal: Curr Opin Cell Biol Date: 2010-10-26 Impact factor: 8.382

10. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries.

Authors: Toshie Kai; Allan Spradling
Journal: Nature Date: 2004-03-14 Impact factor: 49.962

156 in total

Review 1. The retinoblastoma tumor suppressor and stem cell biology.

Authors: Julien Sage
Journal: Genes Dev Date: 2012-07-01 Impact factor: 11.361

2. Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis.

Authors: Johnnie Chau; Laura Shapiro Kulnane; Helen K Salz
Journal: Proc Natl Acad Sci U S A Date: 2012-05-29 Impact factor: 11.205

Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.

1. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development.

Review 2. Intestinal stem cells in mammals and Drosophila.

3. Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis.

4. The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3.

5. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila.

6. Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway.

7. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells.

8. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary.

Review 9. Germ cell sex determination: a collaboration between soma and germline.

10. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries.

Review 1. The retinoblastoma tumor suppressor and stem cell biology.

2. Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis.

Review 3. The hematopoietic stem cell niche in homeostasis and disease.

Review 4. Differentiation and Inflammation: 'Best Enemies' in Gastrointestinal Carcinogenesis.

5. A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary.

Review 6. Nutritional regulation of stem and progenitor cells in Drosophila.

Review 7. Hedgehog in the Drosophila testis niche: what does it do there?

Review 8. Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases.

9. Autophagy Promotes Tumor-like Stem Cell Niche Occupancy.

10. Dissection and Staining of Drosophila Pupal Ovaries.