Literature DB >> 23807635

Hedgehog in the Drosophila testis niche: what does it do there?

Zhao Zhang1, Chenyu Pan2, Yun Zhao3.   

Abstract

Stem cell niche is a specialized microenvironment crucial to self-renewal. The testis in Drosophila contains two different types of stem cells, the germline stem cells and the somatic cyst stem cells that are sustained by their respective niche signals, thus is a good system for studying the interaction between the stem cells and their hosting niche. The JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells, but the roles of several other pathways have emerged recently in a complex signaling network in the testis niche. Reports of independent observations from three research groups have uncovered an important role of Hedgehog (Hh) in the Drosophila testis niche. In this review, we summarize these recent findings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways. We also discuss directions for further investigation.

Entities:  

Keywords:  Drosophila; Hedgehog; JAK-STAT; stem cell; testis

Mesh:

Substances:

Year:  2013        PMID: 23807635      PMCID: PMC4875525          DOI: 10.1007/s13238-013-3040-y

Source DB:  PubMed          Journal:  Protein Cell        ISSN: 1674-800X            Impact factor:   14.870


  56 in total

1.  Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling.

Authors:  N Tulina; E Matunis
Journal:  Science       Date:  2001-12-21       Impact factor: 47.728

2.  The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

Authors:  K W Kinzler; B Vogelstein
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

3.  Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.

Authors:  Nadia Ranieri; Laurent Ruel; Armel Gallet; Sophie Raisin; Pascal P Thérond
Journal:  Dev Cell       Date:  2012-02-02       Impact factor: 12.270

4.  Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

Authors:  Jianhang Jia; Chao Tong; Bing Wang; Liping Luo; Jin Jiang
Journal:  Nature       Date:  2004-12-23       Impact factor: 49.962

5.  Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.

Authors:  A A Kiger; D L Jones; C Schulz; M B Rogers; M T Fuller
Journal:  Science       Date:  2001-12-21       Impact factor: 47.728

6.  Dual roles for patched in sequestering and transducing Hedgehog.

Authors:  Y Chen; G Struhl
Journal:  Cell       Date:  1996-11-01       Impact factor: 41.582

7.  Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused.

Authors:  Kent E Nybakken; Christoph W Turck; David J Robbins; J Michael Bishop
Journal:  J Biol Chem       Date:  2002-04-04       Impact factor: 5.157

8.  Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis.

Authors:  Anish A Shivdasani; Philip W Ingham
Journal:  Curr Biol       Date:  2003-12-02       Impact factor: 10.834

9.  Patched acts catalytically to suppress the activity of Smoothened.

Authors:  J Taipale; M K Cooper; T Maiti; P A Beachy
Journal:  Nature       Date:  2002-08-22       Impact factor: 49.962

10.  Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.

Authors:  Yanyan Zhang; Feifei Mao; Yi Lu; Wenqing Wu; Lei Zhang; Yun Zhao
Journal:  Cell Res       Date:  2011-08-16       Impact factor: 25.617

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  3 in total

1.  Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesis.

Authors:  Michael John Fairchild; Fayeza Islam; Guy Tanentzapf
Journal:  PLoS Genet       Date:  2017-09-28       Impact factor: 5.917

2.  Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile.

Authors:  Marten Michaelis; Alexander Sobczak; Dirk Koczan; Martina Langhammer; Norbert Reinsch; Jennifer Schoen; Joachim M Weitzel
Journal:  BMC Genomics       Date:  2017-11-21       Impact factor: 3.969

Review 3.  Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells.

Authors:  Shiqin Li; Meng Wang; Yanghui Chen; Wei Wang; Junying Wu; Chengpeng Yu; Yuehui Zheng; Zezheng Pan
Journal:  Stem Cells Int       Date:  2017-08-13       Impact factor: 5.443

  3 in total

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