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Literature DB >> 21763600

Beyond stereospecificity: liquids and mesoscale organization of cytoplasm.

Anthony A Hyman¹, Clifford P Brangwynne.

Abstract

The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cytoplasmic organization.

Mesh：

Year: 2011 PMID： 21763600 DOI： 10.1016/j.devcel.2011.06.013

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

53 in total

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Review 3. One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.

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4. Intracellular ice and cell survival in cryo-exposed embryonic axes of recalcitrant seeds of Acer saccharinum: an ultrastructural study of factors affecting cell and ice structures.

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Beyond stereospecificity: liquids and mesoscale organization of cytoplasm.

Review 1. New pathologic mechanisms in nucleotide repeat expansion disorders.

2. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.

Review 3. One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.

4. Intracellular ice and cell survival in cryo-exposed embryonic axes of recalcitrant seeds of Acer saccharinum: an ultrastructural study of factors affecting cell and ice structures.

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7. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics.

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9. Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity.

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