PURPOSE: To investigate possible improvements in predicting the response to neoadjuvant chemotherapy (NAC) at 3 T for locally advanced breast cancer (LABC). MATERIALS AND METHODS: Dynamic contrast-enhanced magnetic resonance (DCE-MR) images acquired before and during NAC were retrospectively analyzed in 85 patients. Tumor volume and diameter, three volumes based on the shape of the enhancement curve, relative signal intensity, area under the curve, and the signal-to-noise ratio were extracted. Differences between responders and nonresponders at the same and between MR timepoints during treatment were evaluated. RESULTS: A higher signal-to-noise ratio was observed on 3 T images compared to 1.5 T, and 3 T revealed more significant findings related to response compared to 1.5 T. The DCE-MRI-derived volume parameters were the earliest predictors of response at both 1.5 and 3 T. CONCLUSION: Our results show that 3 T provides an improved assessment of the response to NAC in LABC patients, where the MR determined tumor volume reduction before the second cycle of NAC was the strongest and earliest predictor of a response.
PURPOSE: To investigate possible improvements in predicting the response to neoadjuvant chemotherapy (NAC) at 3 T for locally advanced breast cancer (LABC). MATERIALS AND METHODS: Dynamic contrast-enhanced magnetic resonance (DCE-MR) images acquired before and during NAC were retrospectively analyzed in 85 patients. Tumor volume and diameter, three volumes based on the shape of the enhancement curve, relative signal intensity, area under the curve, and the signal-to-noise ratio were extracted. Differences between responders and nonresponders at the same and between MR timepoints during treatment were evaluated. RESULTS: A higher signal-to-noise ratio was observed on 3 T images compared to 1.5 T, and 3 T revealed more significant findings related to response compared to 1.5 T. The DCE-MRI-derived volume parameters were the earliest predictors of response at both 1.5 and 3 T. CONCLUSION: Our results show that 3 T provides an improved assessment of the response to NAC in LABC patients, where the MR determined tumor volume reduction before the second cycle of NAC was the strongest and earliest predictor of a response.
Authors: Shelley A Henderson; Nazleen Muhammad Gowdh; Colin A Purdie; Lee B Jordan; Andrew Evans; Tracy Brunton; Alastair M Thompson; Sarah Vinnicombe Journal: Br J Radiol Date: 2018-05-02 Impact factor: 3.039
Authors: Natsuko Onishi; Wen Li; Jessica Gibbs; Lisa J Wilmes; Alex Nguyen; Ella F Jones; Vignesh Arasu; John Kornak; Bonnie N Joe; Laura J Esserman; David C Newitt; Nola M Hylton Journal: Tomography Date: 2020-06