Literature DB >> 21755928

What do medicinal chemists actually make? A 50-year retrospective.

W Patrick Walters1, Jeremy Green, Jonathan R Weiss, Mark A Murcko.   

Abstract

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Year:  2011        PMID： 21755928     DOI： 10.1021/jm200504p

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  48 in total

1.  π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions.

Authors:  Shuming Chen; Amy Y Chan; Morgan M Walker; Jonathan A Ellman; K N Houk
Journal:  J Org Chem       Date:  2018-12-19       Impact factor: 4.354

Review 2.  Finding the sweet spot: the role of nature and nurture in medicinal chemistry.

Authors:  Michael M Hann; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2012-04-30       Impact factor: 84.694

Review 3.  Expanding the medicinal chemistry synthetic toolbox.

Authors:  Jonas Boström; Dean G Brown; Robert J Young; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2018-08-24       Impact factor: 84.694

Review 4.  Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.

Authors:  Damir Bojadzic; Peter Buchwald
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295

Review 5.  The role of ligand efficiency metrics in drug discovery.

Authors:  Andrew L Hopkins; György M Keserü; Paul D Leeson; David C Rees; Charles H Reynolds
Journal:  Nat Rev Drug Discov       Date:  2014-02       Impact factor: 84.694

6.  Efficient discovery of bioactive scaffolds by activity-directed synthesis.

Authors:  George Karageorgis; Stuart Warriner; Adam Nelson
Journal:  Nat Chem       Date:  2014-08-24       Impact factor: 24.427

7.  Tough times for medicinal chemists: are we to blame?

Authors:  Takashi Tsukamoto
Journal:  ACS Med Chem Lett       Date:  2013-03-01       Impact factor: 4.345

8.  The analysis of the market success of FDA approvals by probing top 100 bestselling drugs.

Authors:  Jaroslaw Polanski; Jacek Bogocz; Aleksandra Tkocz
Journal:  J Comput Aided Mol Des       Date:  2016-04-28       Impact factor: 3.686

9.  Expansion of the structure-activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach.

Authors:  Joan Mayol-Llinàs; Shiao Chow; Adam Nelson
Journal:  Medchemcomm       Date:  2019-03-22       Impact factor: 3.597

10.  A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.

Authors:  Robert W Huigens; Karen C Morrison; Robert W Hicklin; Timothy A Flood; Michelle F Richter; Paul J Hergenrother
Journal:  Nat Chem       Date:  2013-01-20       Impact factor: 24.427
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