BACKGROUND: Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. METHODS: By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. RESULTS: All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC. CONCLUSION: This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC.
BACKGROUND: Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. METHODS: By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. RESULTS: All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC. CONCLUSION: This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC.
Authors: Hongyi Wang; Tao Qiu; Jie Shi; Jiulong Liang; Yang Wang; Liangliang Quan; Yu Zhang; Qian Zhang; Kai Tao Journal: Mol Med Rep Date: 2016-01-20 Impact factor: 2.952