5,8-Dimethyl-3-methyl-ene-2-oxo-3,3a,4,5,5a,6,8a,8b-octa-hydro-2H-1-oxa-s-indacene-5-carbaldehyde.

The title compound, C(15)H(18)O(3), was synthesized from 9α-hy-droxy-parthenolide (9α-hy-droxy-4,8-dimethyl-12-methyl-ene-3,14-dioxatricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The five-membered lactone ring has a twisted conformation, while the six- and five-membered rings display chair and envelope conformations, respectively. The dihedral angle between the two five-membered rings is 50.57 (11)°.

Related literature

For the isolation and biological activity of 9α-hy­droxy­parthenolide, see: Abdel Sattar et al. (1996 ▶); El Hassany et al. (2004 ▶). For the reactivity of this sesquiterpene, see: Castaneda-Acosta et al. (1993 ▶); Neukirch et al. (2003 ▶); Der-Ren et al. (2006 ▶); Neelakantan et al. (2009 ▶). For conformational analysis, see: Cremer & Pople (1975 ▶).

Experimental

Crystal data

C15H18O3

M = 246.29

Orthorhombic,

a = 9.5293 (3) Å

b = 9.7885 (3) Å

c = 13.7524 (4) Å

V = 1282.79 (7) Å3

Z = 4

Mo Kα radiation

μ = 0.09 mm−1

T = 173 K

0.50 × 0.33 × 0.08 mm

Data collection

Bruker APEXII CCD area-detector diffractometer

22932 measured reflections

1517 independent reflections

1403 reflections with I > 2σ(I)

R int = 0.026

Refinement

R[F 2 > 2σ(F 2)] = 0.031

wR(F 2) = 0.085

S = 1.09

1517 reflections

165 parameters

H-atom parameters constrained

Δρmax = 0.18 e Å−3

Δρmin = −0.16 e Å−3

Data collection: APEX2 (Bruker, 2005 ▶); cell refinement: APEX2 and SAINT (Bruker, 2005 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶).

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536811018344/sj5146sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536811018344/sj5146Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C15H18O3	F(000) = 528
Mr = 246.29	Dx = 1.275 Mg m−3
Orthorhombic, P212121	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 22932 reflections
a = 9.5293 (3) Å	θ = 2.6–26.4°
b = 9.7885 (3) Å	µ = 0.09 mm−1
c = 13.7524 (4) Å	T = 173 K
V = 1282.79 (7) Å3	Platelet, colourless
Z = 4	0.50 × 0.33 × 0.08 mm

Bruker APEXII CCD area-detector diffractometer	1403 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	Rint = 0.026
graphite	θmax = 26.4°, θmin = 2.6°
φ and ω scans	h = −9→11
22932 measured reflections	k = −12→12
1517 independent reflections	l = −17→17

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.031	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.085	H-atom parameters constrained
S = 1.09	w = 1/[σ2(Fo2) + (0.0511P)2 + 0.1837P] where P = (Fo2 + 2Fc2)/3
1517 reflections	(Δ/σ)max < 0.001
165 parameters	Δρmax = 0.18 e Å−3
0 restraints	Δρmin = −0.16 e Å−3

Geometry. All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.'s are taken into account individually in the estimation of s.u.'s in distances, angles and torsion angles; correlations between s.u.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.

	x	y	z	Uiso*/Ueq
C2	−0.05168 (19)	0.3323 (2)	0.83535 (13)	0.0323 (4)
C3	−0.01615 (19)	0.47821 (19)	0.85677 (12)	0.0307 (4)
C3A	0.12071 (17)	0.47296 (17)	0.91013 (12)	0.0267 (4)
H3	0.0996	0.4573	0.9790	0.032*
C4	0.22933 (18)	0.58577 (18)	0.90494 (13)	0.0301 (4)
H4A	0.1903	0.6701	0.9303	0.036*
H4B	0.2568	0.6010	0.8379	0.036*
C5	0.3576 (2)	0.54344 (18)	0.96536 (13)	0.0311 (4)
C5A	0.40893 (18)	0.39541 (18)	0.94628 (13)	0.0288 (4)
H5A	0.4649	0.3698	1.0032	0.035*
C6	0.5034 (2)	0.3693 (2)	0.85704 (15)	0.0382 (5)
H6A	0.4700	0.4183	0.8003	0.046*
H6B	0.6000	0.3950	0.8699	0.046*
C7	0.4886 (2)	0.2173 (2)	0.84457 (14)	0.0377 (4)
H7	0.5514	0.1638	0.8095	0.045*
C8	0.3756 (2)	0.16819 (18)	0.88923 (12)	0.0321 (4)
C8A	0.29432 (17)	0.28351 (16)	0.93605 (11)	0.0254 (3)
H8A	0.2558	0.2568	0.9993	0.030*
C8B	0.18260 (17)	0.34167 (17)	0.86986 (12)	0.0252 (3)
H8B	0.2253	0.3615	0.8066	0.030*
C9	−0.0975 (2)	0.5818 (2)	0.83263 (14)	0.0386 (4)
H9A	−0.1819	0.5660	0.8006	0.046*
H9B	−0.0705	0.6706	0.8477	0.046*
C10	0.3226 (2)	0.55169 (19)	1.07397 (14)	0.0379 (4)
H10	0.3857	0.5104	1.1164	0.046*
C11	0.4789 (2)	0.6450 (2)	0.95088 (17)	0.0439 (5)
H11A	0.4487	0.7350	0.9691	0.066*
H11B	0.5069	0.6451	0.8838	0.066*
H11C	0.5570	0.6184	0.9907	0.066*
C12	0.3260 (2)	0.02303 (19)	0.89327 (14)	0.0401 (5)
H12A	0.3250	−0.0075	0.9596	0.060*
H12B	0.3882	−0.0337	0.8560	0.060*
H12C	0.2330	0.0173	0.8668	0.060*
O1	0.06185 (12)	0.25263 (13)	0.85447 (9)	0.0302 (3)
O2	−0.16069 (14)	0.28443 (16)	0.80758 (11)	0.0455 (4)
O3	0.22305 (18)	0.60552 (17)	1.10965 (11)	0.0531 (4)

	U11	U22	U33	U12	U13	U23
C2	0.0276 (9)	0.0415 (10)	0.0279 (8)	0.0015 (8)	0.0021 (7)	−0.0003 (8)
C3	0.0266 (8)	0.0389 (9)	0.0266 (8)	0.0034 (8)	0.0031 (7)	0.0002 (7)
C3A	0.0255 (8)	0.0299 (8)	0.0249 (7)	0.0042 (7)	0.0017 (7)	0.0012 (7)
C4	0.0310 (9)	0.0268 (8)	0.0324 (8)	0.0032 (8)	−0.0011 (7)	0.0029 (7)
C5	0.0293 (9)	0.0276 (8)	0.0363 (9)	−0.0007 (8)	−0.0049 (7)	0.0014 (7)
C5A	0.0253 (8)	0.0300 (8)	0.0311 (8)	0.0026 (7)	−0.0042 (7)	0.0048 (7)
C6	0.0260 (9)	0.0436 (11)	0.0450 (10)	0.0037 (8)	0.0069 (8)	0.0072 (9)
C7	0.0337 (10)	0.0403 (10)	0.0391 (10)	0.0121 (9)	0.0021 (8)	−0.0002 (8)
C8	0.0370 (9)	0.0315 (8)	0.0277 (8)	0.0087 (8)	−0.0050 (7)	0.0024 (7)
C8A	0.0284 (8)	0.0252 (7)	0.0224 (7)	0.0017 (7)	−0.0006 (6)	0.0031 (6)
C8B	0.0234 (8)	0.0284 (8)	0.0238 (7)	0.0000 (7)	0.0024 (6)	0.0013 (6)
C9	0.0369 (10)	0.0447 (10)	0.0341 (9)	0.0101 (9)	−0.0045 (8)	0.0023 (8)
C10	0.0452 (11)	0.0324 (9)	0.0361 (9)	−0.0010 (9)	−0.0088 (8)	−0.0034 (7)
C11	0.0363 (10)	0.0347 (10)	0.0607 (13)	−0.0060 (9)	−0.0088 (10)	0.0054 (9)
C12	0.0527 (12)	0.0303 (9)	0.0373 (9)	0.0080 (9)	−0.0072 (9)	−0.0012 (8)
O1	0.0274 (6)	0.0322 (6)	0.0310 (6)	−0.0012 (5)	−0.0001 (5)	−0.0018 (5)
O2	0.0287 (7)	0.0547 (9)	0.0530 (8)	−0.0036 (7)	−0.0043 (6)	−0.0080 (7)
O3	0.0599 (10)	0.0579 (9)	0.0414 (8)	0.0095 (9)	0.0002 (7)	−0.0130 (7)

C2—O2	1.202 (2)	C6—H6B	0.9700
C2—O1	1.360 (2)	C7—C8	1.330 (3)
C2—C3	1.497 (3)	C7—H7	0.9300
C3—C9	1.319 (3)	C8—C12	1.499 (3)
C3—C3A	1.497 (2)	C8—C8A	1.513 (2)
C3A—C4	1.515 (2)	C8A—C8B	1.512 (2)
C3A—C8B	1.519 (2)	C8A—H8A	0.9800
C3A—H3	0.9800	C8B—O1	1.459 (2)
C4—C5	1.535 (2)	C8B—H8B	0.9800
C4—H4A	0.9700	C9—H9A	0.9300
C4—H4B	0.9700	C9—H9B	0.9300
C5—C10	1.533 (3)	C10—O3	1.191 (2)
C5—C11	1.538 (3)	C10—H10	0.9300
C5—C5A	1.552 (2)	C11—H11A	0.9600
C5A—C6	1.544 (3)	C11—H11B	0.9600
C5A—C8A	1.553 (2)	C11—H11C	0.9600
C5A—H5A	0.9800	C12—H12A	0.9600
C6—C7	1.504 (3)	C12—H12B	0.9600
C6—H6A	0.9700	C12—H12C	0.9600
O2—C2—O1	121.68 (18)	C8—C7—H7	123.8
O2—C2—C3	129.07 (18)	C6—C7—H7	123.8
O1—C2—C3	109.23 (15)	C7—C8—C12	128.02 (18)
C9—C3—C2	123.43 (17)	C7—C8—C8A	109.96 (16)
C9—C3—C3A	131.43 (18)	C12—C8—C8A	122.00 (16)
C2—C3—C3A	105.12 (14)	C8B—C8A—C8	112.67 (13)
C3—C3A—C4	123.15 (14)	C8B—C8A—C5A	106.51 (13)
C3—C3A—C8B	100.87 (14)	C8—C8A—C5A	101.81 (14)
C4—C3A—C8B	109.53 (13)	C8B—C8A—H8A	111.8
C3—C3A—H3	107.4	C8—C8A—H8A	111.8
C4—C3A—H3	107.4	C5A—C8A—H8A	111.8
C8B—C3A—H3	107.4	O1—C8B—C8A	114.69 (13)
C3A—C4—C5	108.77 (14)	O1—C8B—C3A	104.61 (13)
C3A—C4—H4A	109.9	C8A—C8B—C3A	111.88 (13)
C5—C4—H4A	109.9	O1—C8B—H8B	108.5
C3A—C4—H4B	109.9	C8A—C8B—H8B	108.5
C5—C4—H4B	109.9	C3A—C8B—H8B	108.5
H4A—C4—H4B	108.3	C3—C9—H9A	120.0
C10—C5—C4	109.89 (16)	C3—C9—H9B	120.0
C10—C5—C11	104.81 (16)	H9A—C9—H9B	120.0
C4—C5—C11	110.74 (15)	O3—C10—C5	126.73 (19)
C10—C5—C5A	106.41 (14)	O3—C10—H10	116.6
C4—C5—C5A	114.30 (15)	C5—C10—H10	116.6
C11—C5—C5A	110.18 (15)	C5—C11—H11A	109.5
C6—C5A—C5	118.22 (15)	C5—C11—H11B	109.5
C6—C5A—C8A	102.79 (14)	H11A—C11—H11B	109.5
C5—C5A—C8A	116.89 (14)	C5—C11—H11C	109.5
C6—C5A—H5A	106.0	H11A—C11—H11C	109.5
C5—C5A—H5A	106.0	H11B—C11—H11C	109.5
C8A—C5A—H5A	106.0	C8—C12—H12A	109.5
C7—C6—C5A	101.51 (16)	C8—C12—H12B	109.5
C7—C6—H6A	111.5	H12A—C12—H12B	109.5
C5A—C6—H6A	111.5	C8—C12—H12C	109.5
C7—C6—H6B	111.5	H12A—C12—H12C	109.5
C5A—C6—H6B	111.5	H12B—C12—H12C	109.5
H6A—C6—H6B	109.3	C2—O1—C8B	108.23 (13)
C8—C7—C6	112.41 (18)