| Literature DB >> 19505822 |
Sundar Neelakantan1, Shama Nasim, Monica L Guzman, Craig T Jordan, Peter A Crooks.
Abstract
A series of aminoparthenolide analogs (6-37) were synthesized and evaluated for their anti-leukemic activity. Eight compounds exhibited good anti-leukemic activity with LD(50)'s in the low microM range (1.5-3.0microM). Compounds 16, 24 and 30 were the most potent compounds in the series, causing greater than 90% cell death at 10microM concentration against primary AML cells in culture, with LD(50) values of 1.7, 1.8 and 1.6microM.Entities:
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Year: 2009 PMID： 19505822 DOI： 10.1016/j.bmcl.2009.05.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823