Beena D Kamath1, Michael P Marcotte, Emily A DeFranco. 1. Division of Neonatology and Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH 45229, USA. beena.kamath@cchmc.org
Abstract
OBJECTIVE: Fetal lung maturity often is used as the sole criterion that late preterm infants are ready for postnatal life. We therefore tested the hypothesis that fetal lung maturity testing does not predict the absence of morbidity in late preterm infants. STUDY DESIGN: We performed a retrospective cohort study to examine 152 infants who were born in the late preterm (34 0/7 to 36 6/7 weeks) and early term (37 0/7 to 38 6/7 weeks) periods after mature fetal lung indices and compared them with 262 infants who were born at ≥39 weeks' gestation and who were matched by mode of delivery. RESULTS: Despite documented fetal lung maturity, infants who were born at <39 weeks had significantly higher rates of neonatal morbidities compared with infants who were born at ≥39 weeks' gestation. After adjustment for significant covariates, we found that infants who were born at <39 weeks' gestation had an increased risk of composite adverse outcome (odds ratio, 3.66; 95% confidence interval, 1.48-9.09; P < .01). CONCLUSION: Fetal lung maturity testing is insufficient to determine an infant's readiness for postnatal life.
OBJECTIVE: Fetal lung maturity often is used as the sole criterion that late preterm infants are ready for postnatal life. We therefore tested the hypothesis that fetal lung maturity testing does not predict the absence of morbidity in late preterm infants. STUDY DESIGN: We performed a retrospective cohort study to examine 152 infants who were born in the late preterm (34 0/7 to 36 6/7 weeks) and early term (37 0/7 to 38 6/7 weeks) periods after mature fetal lung indices and compared them with 262 infants who were born at ≥39 weeks' gestation and who were matched by mode of delivery. RESULTS: Despite documented fetal lung maturity, infants who were born at <39 weeks had significantly higher rates of neonatal morbidities compared with infants who were born at ≥39 weeks' gestation. After adjustment for significant covariates, we found that infants who were born at <39 weeks' gestation had an increased risk of composite adverse outcome (odds ratio, 3.66; 95% confidence interval, 1.48-9.09; P < .01). CONCLUSION: Fetal lung maturity testing is insufficient to determine an infant's readiness for postnatal life.
Authors: Elizabeth Bates; Dwight J Rouse; Merry Lynn Mann; Victoria Chapman; Waldemar A Carlo; Alan T N Tita Journal: Obstet Gynecol Date: 2010-12 Impact factor: 7.661
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Alan T N Tita; Mark B Landon; Catherine Y Spong; Yinglei Lai; Kenneth J Leveno; Michael W Varner; Atef H Moawad; Steve N Caritis; Paul J Meis; Ronald J Wapner; Yoram Sorokin; Menachem Miodovnik; Marshall Carpenter; Alan M Peaceman; Mary J O'Sullivan; Baha M Sibai; Oded Langer; John M Thorp; Susan M Ramin; Brian M Mercer Journal: N Engl J Med Date: 2009-01-08 Impact factor: 91.245
Authors: Alan T N Tita; Kathleen A Jablonski; Jennifer L Bailit; William A Grobman; Ronald J Wapner; Uma M Reddy; Michael W Varner; John M Thorp; Kenneth J Leveno; Steve N Caritis; Jay D Iams; George Saade; Yoram Sorokin; Dwight J Rouse; Sean C Blackwell; Jorge E Tolosa Journal: Am J Obstet Gynecol Date: 2018-05-22 Impact factor: 8.661
Authors: Lucy Liu; Methodius G Tuuli; Kimberly A Roehl; Anthony O Odibo; George A Macones; Alison G Cahill Journal: Am J Obstet Gynecol Date: 2015-07-17 Impact factor: 8.661
Authors: Yasmin Essameldin Abdalla Khalifa; Mona M Aboulghar; Soha T Hamed; Rania H Tomerak; Ahmed M Asfour; Eman F Kamal Journal: Br J Radiol Date: 2021-11-10 Impact factor: 3.039
Authors: Beena D Kamath-Rayne; Yina Du; Maria Hughes; Erin A Wagner; Louis J Muglia; Emily A DeFranco; Jeffrey A Whitsett; Nathan Salomonis; Yan Xu Journal: BMC Med Genomics Date: 2015-10-22 Impact factor: 3.063