Literature DB >> 21751402

Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.

Wenwen Chen1, Irina N Gaisina, Hendra Gunosewoyo, Sam A Malekiani, Taleen Hanania, Alan P Kozikowski.   

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Year:  2011        PMID： 21751402      PMCID： PMC3428241          DOI： 10.1002/cmdc.201100231

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  21 in total

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3.  SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

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4.  A molecular mechanism for the effect of lithium on development.

Authors:  P S Klein; D A Melton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

5.  Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

Authors:  L Meijer; A M Thunnissen; A W White; M Garnier; M Nikolic; L H Tsai; J Walter; K E Cleverley; P C Salinas; Y Z Wu; J Biernat; E M Mandelkow; S H Kim; G R Pettit
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Review 6.  GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?

Authors:  Ana Martinez; Daniel I Perez
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7.  GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

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Journal:  Nature       Date:  2003-05-22       Impact factor: 49.962

8.  Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.

Authors:  Alan P Kozikowski; Irina N Gaisina; Hongbin Yuan; Pavel A Petukhov; Sylvie Y Blond; Allison Fedolak; Barbara Caldarone; Paul McGonigle
Journal:  J Am Chem Soc       Date:  2007-06-07       Impact factor: 15.419

9.  GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Authors:  Laurent Meijer; Alexios-Leandros Skaltsounis; Prokopios Magiatis; Panagiotis Polychronopoulos; Marie Knockaert; Maryse Leost; Xiaozhou P Ryan; Claudia Alin Vonica; Ali Brivanlou; Rana Dajani; Claudia Crovace; Cataldo Tarricone; Andrea Musacchio; S Mark Roe; Laurence Pearl; Paul Greengard
Journal:  Chem Biol       Date:  2003-12

10.  Lithium side effects in relation to dose and to levels and gradients of lithium in plasma.

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Journal:  Acta Psychiatr Scand       Date:  1977-03       Impact factor: 6.392
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1.  Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.

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2.  Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.

Authors:  Yuki Yoshino; Chikashi Ishioka
Journal:  Sci Rep       Date:  2015-08-21       Impact factor: 4.379

Review 3.  Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.

Authors:  Zefeng Zhao; Xufen Dai; Chenyang Li; Xiao Wang; Jiale Tian; Ying Feng; Jing Xie; Cong Ma; Zhuang Nie; Peinan Fan; Mingcheng Qian; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Eur J Med Chem       Date:  2019-11-16       Impact factor: 6.514

4.  Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.

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  4 in total

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