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Literature DB >> 21749075

Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.

David E Williams¹, Doralyn S Dalisay, Brian O Patrick, Teatulohi Matainaho, Kerry Andrusiak, Raamesh Deshpande, Chad L Myers, Jeff S Piotrowski, Charles Boone, Minoru Yoshida, Raymond J Andersen.

Abstract

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2011 PMID： 21749075 PMCID： PMC3152301 DOI： 10.1021/ol2014494

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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