A Ghasemi1, S Zahediasl, L Syedmoradi, F Azizi. 1. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
AIM: Endothelial dysfunction and impaired release of endothelial nitric oxide occurs in hypertension. The aim of this study was to determine the relation between nitric oxide metabolites (NOx) concentrations and blood pressure levels in a general population. METHODS: In a cross-sectional study, NO(x)was measured in 2,968 adult subjects, randomly selected from a population-based study, using the Griess method. Subjects were classified into normal, prehypertension, stage 1 hypertension and stage two hypertension groups, according to the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. RESULTS: Serum NO(x)values were negatively correlated with systolic blood pressure ≥160 mm Hg in men (r=-0.523, P=0.002). Serum NOx was higher in men with stage 1 hypertension while those with stage 2 hypertension had significantly lower NO(x) levels. In men, medication increased serum NO(x) concentration in both stages of hypertension but in women, a significant increase was observed only in stage 1 hypertension. CONCLUSION: Serum NO(x) concentrations decreased in untreated stage 2 hypertension and increased in stage 1 hypertension in men, findings that suggest NOx measurement might be helpful for assessing endothelial (dys) function in male hypertensive subjects.
AIM: Endothelial dysfunction and impaired release of endothelial nitric oxide occurs in hypertension. The aim of this study was to determine the relation between nitric oxide metabolites (NOx) concentrations and blood pressure levels in a general population. METHODS: In a cross-sectional study, NO(x)was measured in 2,968 adult subjects, randomly selected from a population-based study, using the Griess method. Subjects were classified into normal, prehypertension, stage 1 hypertension and stage two hypertension groups, according to the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. RESULTS: Serum NO(x)values were negatively correlated with systolic blood pressure ≥160 mm Hg in men (r=-0.523, P=0.002). Serum NOx was higher in men with stage 1 hypertension while those with stage 2 hypertension had significantly lower NO(x) levels. In men, medication increased serum NO(x) concentration in both stages of hypertension but in women, a significant increase was observed only in stage 1 hypertension. CONCLUSION: Serum NO(x) concentrations decreased in untreated stage 2 hypertension and increased in stage 1 hypertension in men, findings that suggest NOx measurement might be helpful for assessing endothelial (dys) function in male hypertensive subjects.
Authors: Andrew S Cowburn; Norihiko Takeda; Adam T Boutin; Jung-Whan Kim; Jane C Sterling; Manando Nakasaki; Mark Southwood; Ananda W Goldrath; Colin Jamora; Victor Nizet; Edwin R Chilvers; Randall S Johnson Journal: Proc Natl Acad Sci U S A Date: 2013-10-07 Impact factor: 11.205