Literature DB >> 21745833

Level of consciousness in dying patients. The role of palliative sedation: a longitudinal prospective study.

Patricia Claessens1, Johan Menten, Paul Schotsmans, Bert Broeckaert.   

Abstract

BACKGROUND: Patients suffering from a terminal illness often are confronted with severe symptoms during the last phase of their lives. Palliative sedation, although one of the options of last resort, remains a much debated and controversial issue and is often referred to as a form of slow euthanasia or euthanasia in disguise.
METHODS: A prospective longitudinal and descriptive design was used. Each patient admitted in one of the 8 participating units was included if they met the inclusion criteria and gave written informed consent.
RESULTS: 266 patients were included. The incidence of palliative sedation was 7;5%. For the group of sedated patients results show that 90% entered the palliative care unit being fully conscious. Two patients were comatose upon arrival. 90% of the patients remained fully conscious up to the day palliative sedation was started. When looking at the effect of palliative sedation on the level of consciousness the analysis strongly suggest that the palliative sedation - as expected- has an impact on the GCS score. Irrespective of the dichotomization of the score the probability of having a lower GCS increases substantially once sedation is initiated. Additionally, results show that once palliative sedation is administered, the level of consciousness gradually goes down up until the day of death.
CONCLUSION: Palliative sedation is nor slow euthanasia nor an ambivalent practice. It is an intentional medical treatment which is administered in a proportional way when refractory suffering occurs. It occurs in extraordinary situations and at the very end of the dying process.

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Year:  2011        PMID: 21745833     DOI: 10.1177/1049909111413890

Source DB:  PubMed          Journal:  Am J Hosp Palliat Care        ISSN: 1049-9091            Impact factor:   2.500


  10 in total

1.  Palliative sedation, foregoing life-sustaining treatment, and aid-in-dying: what is the difference?

Authors:  Patrick Daly
Journal:  Theor Med Bioeth       Date:  2015-06

Review 2.  Beyond integrating social sciences: Reflecting on the place of life sciences in empirical bioethics methodologies.

Authors:  Marcel Mertz; Jan Schildmann
Journal:  Med Health Care Philos       Date:  2018-06

3.  Current debates on end-of-life sedation: an international expert elicitation study.

Authors:  Evangelia Evie Papavasiliou; Sheila Payne; Sarah Brearley
Journal:  Support Care Cancer       Date:  2014-03-20       Impact factor: 3.603

Review 4.  Distancing sedation in end-of-life care from physician-assisted suicide and euthanasia.

Authors:  Tze Ling Gwendoline Beatrice Soh; Lalit Kumar Radha Krishna; Shin Wei Sim; Alethea Chung Peng Yee
Journal:  Singapore Med J       Date:  2016-05       Impact factor: 1.858

5.  [Palliative sedation for psycho-existential suffering].

Authors:  Eva Weichselbaumer; Dietmar Weixler
Journal:  Wien Med Wochenschr       Date:  2013-10-25

Review 6.  Palliative Sedation for the Terminally Ill Patient.

Authors:  Ferdinando Garetto; Ferdinando Cancelli; Romina Rossi; Marco Maltoni
Journal:  CNS Drugs       Date:  2018-10       Impact factor: 5.749

Review 7.  Palliative pharmacological sedation for terminally ill adults.

Authors:  Elaine M Beller; Mieke L van Driel; Leanne McGregor; Shani Truong; Geoffrey Mitchell
Journal:  Cochrane Database Syst Rev       Date:  2015-01-02

8.  Identification and evaluation of observational measures for the assessment and/or monitoring of level of consciousness in adult palliative care patients: A systematic review for I-CAN-CARE.

Authors:  Anna-Maria Krooupa; Bella Vivat; Stephen McKeever; Elena Marcus; Joseph Sawyer; Paddy Stone
Journal:  Palliat Med       Date:  2019-08-22       Impact factor: 5.713

Review 9.  How to measure the effects and potential adverse events of palliative sedation? An integrative review.

Authors:  Alazne Belar; María Arantzamendi; Sheila Payne; Nancy Preston; Maaike Rijpstra; Jeroen Hasselaar; Lukas Radbruch; Michael Vanderelst; Julie Ling; Carlos Centeno
Journal:  Palliat Med       Date:  2020-12-14       Impact factor: 4.762

Review 10.  General anaesthesia in end-of-life care: extending the indications for anaesthesia beyond surgery.

Authors:  A Takla; J Savulescu; D J C Wilkinson; J J Pandit
Journal:  Anaesthesia       Date:  2021-04-20       Impact factor: 12.893

  10 in total

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