Literature DB >> 21744818

Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries.

Craig E Stivala1, Armen Zakarian.   

Abstract

A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.
© 2011 American Chemical Society

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Year:  2011        PMID： 21744818      PMCID： PMC3373785          DOI： 10.1021/ja205107x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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