PURPOSE: To assess whether depression symptoms, poor sleep and dry skin bother explain association between pruritus and the burden of kidney disease in maintenance hemodialysis (MHD) patients. METHODS: Cross-sectional study of 980 patients from a prospective study in dialysis units of Salvador, Brazil (PROHEMO). The Kidney Disease Quality of Life Short Form was used to determine scores of kidney disease burden (KDB) and sleep with higher scores indicating lower perceived burden and better sleep quality, respectively. The Center for Epidemiological Studies Depression Scale was used for depression symptoms. RESULTS: Prevalence of severe pruritus (very much or extreme) was 19.4%. Significantly (P < 0.001) lower mean KDB score by 11.44 points was observed for patients with severe pruritus (34.18 ± 27.51) than for those with no pruritus (45.62 ± 30.73). Severe pruritus was associated with poorer sleep quality, higher odds of dry skin bother and higher depression symptoms score. Association of pruritus with KDB score was virtually eliminated after adjustment for sleep, dry skin bother and depression symptoms. CONCLUSIONS: This study shows strong associations of severe pruritus with higher depression symptoms, poorer sleep and dry skin bother among MHD patients. The results support special attention to MHD patients with pruritus who often face high psychological burden.
PURPOSE: To assess whether depression symptoms, poor sleep and dry skin bother explain association between pruritus and the burden of kidney disease in maintenance hemodialysis (MHD) patients. METHODS: Cross-sectional study of 980 patients from a prospective study in dialysis units of Salvador, Brazil (PROHEMO). The Kidney Disease Quality of Life Short Form was used to determine scores of kidney disease burden (KDB) and sleep with higher scores indicating lower perceived burden and better sleep quality, respectively. The Center for Epidemiological Studies Depression Scale was used for depression symptoms. RESULTS: Prevalence of severe pruritus (very much or extreme) was 19.4%. Significantly (P < 0.001) lower mean KDB score by 11.44 points was observed for patients with severe pruritus (34.18 ± 27.51) than for those with no pruritus (45.62 ± 30.73). Severe pruritus was associated with poorer sleep quality, higher odds of dry skin bother and higher depression symptoms score. Association of pruritus with KDB score was virtually eliminated after adjustment for sleep, dry skin bother and depression symptoms. CONCLUSIONS: This study shows strong associations of severe pruritus with higher depression symptoms, poorer sleep and dry skin bother among MHD patients. The results support special attention to MHD patients with pruritus who often face high psychological burden.
Authors: Gildete Barreto Lopes; Cácia Mendes Matos; Eneida Barreto Leite; Maria Tereza Silveira Martins; Márcia Silva Martins; Luciana Ferreira Silva; Bruce M Robinson; Friedrich K Port; Sherman A James; Antonio Alberto Lopes Journal: Nephron Clin Pract Date: 2010-02-19
Authors: Martin Kimmel; Dominik Mark Alscher; Robert Dunst; Niko Braun; Christoph Machleidt; Thomas Kiefer; Christina Stülten; Heiko van der Kuip; Christiane Pauli-Magnus; Ulrich Raub; Ulrich Kuhlmann; Thomas Mettang Journal: Nephrol Dial Transplant Date: 2005-10-25 Impact factor: 5.992
Authors: Vandana S Mathur; Jill Lindberg; Michael Germain; Geoffrey Block; James Tumlin; Mark Smith; Mandeep Grewal; Dawn McGuire Journal: Clin J Am Soc Nephrol Date: 2010-06-17 Impact factor: 8.237
Authors: Y Yamamoto; Y Hayashino; S Yamazaki; T Akiba; T Akizawa; Y Asano; A Saito; K Kurokawa; Y Miyachi; S Fukuhara Journal: Br J Dermatol Date: 2009-03-09 Impact factor: 9.302
Authors: Natalia C V Melo; Rosilene M Elias; Manuel Carlos M Castro; Joao E Romao; Hugo Abensur Journal: Hemodial Int Date: 2009-01 Impact factor: 1.812
Authors: Nidhi Sukul; Elodie Speyer; Charlotte Tu; Brian A Bieber; Yun Li; Antonio A Lopes; Koichi Asahi; Laura Mariani; Maurice Laville; Hugh C Rayner; Bénédicte Stengel; Bruce M Robinson; Ronald L Pisoni Journal: Clin J Am Soc Nephrol Date: 2019-04-11 Impact factor: 8.237
Authors: Sara N Davison; Adeera Levin; Alvin H Moss; Vivekanand Jha; Edwina A Brown; Frank Brennan; Fliss E M Murtagh; Saraladevi Naicker; Michael J Germain; Donal J O'Donoghue; Rachael L Morton; Gregorio T Obrador Journal: Kidney Int Date: 2015-04-29 Impact factor: 10.612
Authors: Mohamed K Ibrahim; Ahmed R Elshahid; Tarek Z El Baz; Raed M Elazab; Sara A Elhoseiny; Mohamed L Elsaie Journal: J Clin Diagn Res Date: 2016-03-01
Authors: B Güvercin; K Kaynar; D A Arıca; B V Kural; Ş Ulusoy; M Cansız; L B Selçuk; A Akyüz; C C Kolaylı Journal: Hippokratia Date: 2019 Apr-Jun Impact factor: 0.471
Authors: Rilma F S Santos; Gildásio C Conceição; Márcia S Martins; Angiolina Kraychete; Maria A C Penalva; Edgar M Carvalho; Antonio Alberto Lopes; Paulo Novis Rocha Journal: BMC Nephrol Date: 2017-02-15 Impact factor: 2.388
Authors: Inayat Ur Rehman; Raheel Ahmed; Aziz Ur Rahman; David Bin Chia Wu; Syed Munib; Yasar Shah; Nisar Ahmad Khan; Ateeq Ur Rehman; Learn Han Lee; Kok Gan Chan; Tahir Mehmood Khan Journal: Medicine (Baltimore) Date: 2021-05-28 Impact factor: 1.889