BACKGROUND: Recent reports suggest a cross-sectional association between psychiatric distress and pruritus in patients on haemodialysis (HD). However, no study has examined the likelihood of developing severe pruritus in patients on HD with depressive symptoms. OBJECTIVES: To evaluate the relationship between baseline depressive symptoms and subsequent risk of developing severe pruritus. METHODS: A longitudinal study with a 0.5-2.5-year follow-up period was performed using 1799 patients on HD who had no/mild pruritus at baseline, based on the Japan Dialysis Outcomes and Practice Patterns Study (1996-2004), a cohort study composed of a representative sample of patients on HD. We assessed pruritus after the follow-up period using a self-reported questionnaire and depressive symptoms using scores from the five-item version of the Mental Health Inventory (MHI-5). RESULTS: The 1799 patients had a mean age of 56.9 years, 59.5% were men, and 23.6% presented depressive symptoms. Multivariable analysis revealed that patients with depressive symptoms had significantly higher odds of developing severe pruritus during the 0.5-2.5-year follow-up period [adjusted odds ratio (AOR) 1.57, 95% confidence interval 1.22-2.01, P < 0.001]. In addition, a significant linear trend was observed between baseline MHI-5 scores and risk of developing severe pruritus, with AORs for third, second and first MHI-5 score quartiles of 1.08, 1.51 and 1.95, respectively (P for trend < 0.0001). CONCLUSIONS: Our results suggest that depressive symptoms measured by MHI-5 may predict the future risk of developing severe pruritus in patients on HD.
BACKGROUND: Recent reports suggest a cross-sectional association between psychiatric distress and pruritus in patients on haemodialysis (HD). However, no study has examined the likelihood of developing severe pruritus in patients on HD with depressive symptoms. OBJECTIVES: To evaluate the relationship between baseline depressive symptoms and subsequent risk of developing severe pruritus. METHODS: A longitudinal study with a 0.5-2.5-year follow-up period was performed using 1799 patients on HD who had no/mild pruritus at baseline, based on the Japan Dialysis Outcomes and Practice Patterns Study (1996-2004), a cohort study composed of a representative sample of patients on HD. We assessed pruritus after the follow-up period using a self-reported questionnaire and depressive symptoms using scores from the five-item version of the Mental Health Inventory (MHI-5). RESULTS: The 1799 patients had a mean age of 56.9 years, 59.5% were men, and 23.6% presented depressive symptoms. Multivariable analysis revealed that patients with depressive symptoms had significantly higher odds of developing severe pruritus during the 0.5-2.5-year follow-up period [adjusted odds ratio (AOR) 1.57, 95% confidence interval 1.22-2.01, P < 0.001]. In addition, a significant linear trend was observed between baseline MHI-5 scores and risk of developing severe pruritus, with AORs for third, second and first MHI-5 score quartiles of 1.08, 1.51 and 1.95, respectively (P for trend < 0.0001). CONCLUSIONS: Our results suggest that depressive symptoms measured by MHI-5 may predict the future risk of developing severe pruritus in patients on HD.
Authors: Gildete Barreto Lopes; Fernanda Conceição Pereira Nogueira; Milena Reis de Souza; Maria Auxiliadora Penalva; Josete Leão de Amorim; Ronald L Pisoni; Bruce M Robinson; Antonio Alberto Lopes Journal: Qual Life Res Date: 2011-07-09 Impact factor: 4.147
Authors: Sônia M H A Araujo; Veralice M S de Bruin; Elizabeth de F Daher; Gilson H Almeida; Camila A M Medeiros; Pedro Felipe C de Bruin Journal: Int Urol Nephrol Date: 2011-07-22 Impact factor: 2.370
Authors: Mark Unruh; Manjula Kurella Tamura; Brett Larive; Anjay Rastogi; Sam James; Brigitte Schiller; Jennifer Gassman; Christopher Chan; Robert Lockridge; Alan Kliger Journal: Am J Nephrol Date: 2011-04-08 Impact factor: 3.754
Authors: Nidhi Sukul; Angelo Karaboyas; Philipp A Csomor; Thilo Schaufler; Warren Wen; Frédérique Menzaghi; Hugh C Rayner; Takeshi Hasegawa; Issa Al Salmi; Saeed M G Al-Ghamdi; Fitsum Guebre-Egziabher; Pablo-Antonio Ureña-Torres; Ronald L Pisoni Journal: Kidney Med Date: 2020-11-21