INTRODUCTION: Recurrent gliomas are usually histologically high grade; either due to recurrence of a de novo high-grade primary or anaplastic transformation in case of low-grade tumors. Survival in these patients is variable. The objective of the present study is to evaluate the role of FDG PET-CT for predicting survival in a large group of patients with suspected recurrent glioma. METHODS: A total of 81 previously treated histopathologically proven glioma patients; with clinical and conventional imaging findings suspicious of recurrence were included in this study. All patients underwent FDG PET-CT study. Based on tumor to white matter (T/W) and tumor to grey matter (T/G) ratios, all lesions were scored on PET-CT (PET scores 0, 1 and 2). Patients were followed up clinically and by repeated imaging. Data was censored, if the patient died of disease or at the end of the study. Survival analysis was done for each variable employing univariate analysis followed by multivariate analysis, using variables found significant on univariate analysis. RESULTS: PET score was found to be the most significant predictor of survival in univariate and multivariate analysis (p 0.003). Patients having PET score 2 had poorer survival compared to both PET score 0 (p 0.001) and PET score 1 (p 0.004). Other covariates found to have significant correlation with survival were primary treatment modality and clinical symptoms at the time of recurrence. CONCLUSION: FDG uptake on PET-CT is a strong predictor of survival in patients with suspected recurrent glioma.
INTRODUCTION: Recurrent gliomas are usually histologically high grade; either due to recurrence of a de novo high-grade primary or anaplastic transformation in case of low-grade tumors. Survival in these patients is variable. The objective of the present study is to evaluate the role of FDG PET-CT for predicting survival in a large group of patients with suspected recurrent glioma. METHODS: A total of 81 previously treated histopathologically proven gliomapatients; with clinical and conventional imaging findings suspicious of recurrence were included in this study. All patients underwent FDG PET-CT study. Based on tumor to white matter (T/W) and tumor to grey matter (T/G) ratios, all lesions were scored on PET-CT (PET scores 0, 1 and 2). Patients were followed up clinically and by repeated imaging. Data was censored, if the patient died of disease or at the end of the study. Survival analysis was done for each variable employing univariate analysis followed by multivariate analysis, using variables found significant on univariate analysis. RESULTS: PET score was found to be the most significant predictor of survival in univariate and multivariate analysis (p 0.003). Patients having PET score 2 had poorer survival compared to both PET score 0 (p 0.001) and PET score 1 (p 0.004). Other covariates found to have significant correlation with survival were primary treatment modality and clinical symptoms at the time of recurrence. CONCLUSION:FDG uptake on PET-CT is a strong predictor of survival in patients with suspected recurrent glioma.
Authors: G Bauman; K Lote; D Larson; L Stalpers; C Leighton; B Fisher; W Wara; D MacDonald; L Stitt; J G Cairncross Journal: Int J Radiat Oncol Biol Phys Date: 1999-11-01 Impact factor: 7.038
Authors: V Jung; B F Romeike; W Henn; W Feiden; J R Moringlane; K D Zang; S Urbschat Journal: J Neuropathol Exp Neurol Date: 1999-09 Impact factor: 3.685
Authors: D Kahn; K A Follett; D L Bushnell; M A Nathan; J G Piper; M Madsen; P T Kirchner Journal: AJR Am J Roentgenol Date: 1994-12 Impact factor: 3.959
Authors: Benoit Pirotte; Serge Goldman; Nicolas Massager; Philippe David; David Wikler; Arlette Vandesteene; Isabelle Salmon; Jacques Brotchi; Marc Levivier Journal: J Nucl Med Date: 2004-08 Impact factor: 10.057
Authors: C S Brock; H Young; S M O'Reilly; J Matthews; S Osman; H Evans; E S Newlands; P M Price Journal: Br J Cancer Date: 2000-02 Impact factor: 7.640
Authors: Joshua D Bernstock; Sam E Gary; Neil Klinger; Pablo A Valdes; Walid Ibn Essayed; Hannah E Olsen; Gustavo Chagoya; Galal Elsayed; Daisuke Yamashita; Patrick Schuss; Florian A Gessler; Pier Paolo Peruzzi; Asim K Bag; Gregory K Friedman Journal: Neurooncol Adv Date: 2022-05-26
Authors: Jason R Buck; Eliot T McKinley; Allie Fu; Ty W Abel; Reid C Thompson; Lola Chambless; Jennifer M Watchmaker; James P Harty; Michael K Cooper; H Charles Manning Journal: PLoS One Date: 2015-10-30 Impact factor: 3.240
Authors: Timothy P C Yeung; Slav Yartsev; Ting-Yim Lee; Eugene Wong; Wenqing He; Barbara Fisher; Lauren L VanderSpek; David Macdonald; Glenn Bauman Journal: J Med Radiat Sci Date: 2014-01-16
Authors: Sarah Jost Fouke; Tammie Benzinger; Daniel Gibson; Timothy C Ryken; Steven N Kalkanis; Jeffrey J Olson Journal: J Neurooncol Date: 2015-11-03 Impact factor: 4.130