BACKGROUND AND PURPOSE: With the development of flattening filter-free linear accelerators for radiotherapy, the instantaneous dose rate has increased by approximately a factor 4. This leads to the question of whether there may be a radiobiological consequence. The present study investigates the radiobiological effect of this high instantaneous dose rate on two cell lines. MATERIALS AND METHODS: A Varian Trilogy TX linear accelerator was used to directly compare the effect of three different dose rates (5.01, 9.99 and 29.91 Gy/min, with instantaneous dose rates in the pulse of 56.5, 112.8 and 338 Gy/s) on clonogenic survival. V79 and FaDu(DD) cells were irradiated with doses in a range from 1 to 10 Gy in order to obtain dose response curves. RESULTS: For both cell lines, there is not observed any effect of the instantaneous dose rate on cell survival. Copyright Â
BACKGROUND AND PURPOSE: With the development of flattening filter-free linear accelerators for radiotherapy, the instantaneous dose rate has increased by approximately a factor 4. This leads to the question of whether there may be a radiobiological consequence. The present study investigates the radiobiological effect of this high instantaneous dose rate on two cell lines. MATERIALS AND METHODS: A Varian Trilogy TX linear accelerator was used to directly compare the effect of three different dose rates (5.01, 9.99 and 29.91 Gy/min, with instantaneous dose rates in the pulse of 56.5, 112.8 and 338 Gy/s) on clonogenic survival. V79 and FaDu(DD) cells were irradiated with doses in a range from 1 to 10 Gy in order to obtain dose response curves. RESULTS: For both cell lines, there is not observed any effect of the instantaneous dose rate on cell survival. Copyright Â
Authors: Caroline Steenken; Jens Fleckenstein; Stefan Kegel; Lennart Jahnke; Anna Simeonova; Linda Hartmann; Jens Kübler; Marlon R Veldwijk; Frederik Wenz; Carsten Herskind; Frank Anton Giordano Journal: Strahlenther Onkol Date: 2015-03-13 Impact factor: 3.621
Authors: Brendan M Prendergast; Michael C Dobelbower; James A Bonner; Richard A Popple; Craig J Baden; Douglas J Minnich; Robert J Cerfolio; Sharon A Spencer; John B Fiveash Journal: Radiat Oncol Date: 2013-11-20 Impact factor: 3.481
Authors: Juliane Rieber; Eric Tonndorf-Martini; Oliver Schramm; Bernhard Rhein; Laila König; Sebastian Adeberg; Eva Meyerhof; Angela Mohr; Jutta Kappes; Hans Hoffmann; Jürgen Debus; Stefan Rieken Journal: Radiat Oncol Date: 2016-06-08 Impact factor: 3.481