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Literature DB >> 217349

Partial reversal of the acetaldehyde and butyraldehyde oxidation reactions catalysed by aldehyde dehydrogenases from sheep liver.

Abstract

In the presence of acetic anhydride or butyric anhydride, liver aldehyde dehydrogenases catalyse the oxidation of NADH at pH 7.0 and 25 degrees C. The maximum velocities and Michaelis constants for NADH at saturating anhydride concentrations are independent of which anhydride is used, the values being V'max. = 12 min-1 and Km for NADH = 9 micrometer for the mitochondrial enzyme and V'max = 25 min-1 and Km for NADH = 20 micrometer for the cytoplasmic enzyme. Substitution of [4A-2H]NADH for NADH resulted in 2-fold and 4-fold decreases in rate for the mitochondrial and cytoplasmic enzymes respectively.

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Year: 1978 PMID： 217349 PMCID： PMC1186126 DOI： 10.1042/bj1750753

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Some observations on the preparation and properties of dihydronicotinamide-adenine dinucleotide.

Authors: K DALZIEL
Journal: Biochem J Date: 1962-08 Impact factor: 3.857

2. The stereospecificity of enzymatic hydrogen transfer from diphosphopyridine nucleotide.

Authors: H R LEVY; B VENNESLAND
Journal: J Biol Chem Date: 1957-09 Impact factor: 5.157

3. The oxidation of acetaldehyde to acetyl coenzyme A.

Authors: R M BURTON; E R STADTMAN
Journal: J Biol Chem Date: 1953-06 Impact factor: 5.157

4. Some properties of aldehyde dehydrogenase from sheep liver mitochondria.

Authors: G J Hart; F M Dickinson
Journal: Biochem J Date: 1977-05-01 Impact factor: 3.857

5. Steady-state and pre-steady kinetic studies on mitochondrial sheep liver aldehyde dehydrogenase. A comparison with the cytoplasmic enzyme.

Authors: A K MacGibbon; L F Blackwell; P D Buckley
Journal: Biochem J Date: 1978-06-01 Impact factor: 3.857

6. Kinetics of sheep-liver cytoplasmic aldehyde dehydrogenase.

Authors: A K MacGibbon; L F Blackwell; P D Buckley
Journal: Eur J Biochem Date: 1977-07-01

7. Pre-steady-state kinetic studies on cytoplasmic sheep liver aldehyde dehydrogenase.

Authors: A K MacGibbon; L F Blackwell; P D Buckley
Journal: Biochem J Date: 1977-11-01 Impact factor: 3.857

8. Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver.

Authors: K E Crow; T M Kitson; A K MacGibbon; R D Batt
Journal: Biochim Biophys Acta Date: 1974-05-20

9. Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity.

Authors: R I Feldman; H Weiner
Journal: J Biol Chem Date: 1972-01-10 Impact factor: 5.157

10. The action of progesterone and diethylstilboestrol on the dehydrogenase and esterase activities of a purified aldehyde dehydrogenase from rabbit liver.

Authors: R Julian; S Duncan
Journal: Biochem J Date: 1977-01-01 Impact factor: 3.857

8 in total

1. Studies on the mechanism of sheep liver cytosolic aldehyde dehydrogenase. The effect of pH on the aldehyde binding reactions and a re-examination of the problem of the site of proton release in the mechanism.

Authors: F M Dickinson
Journal: Biochem J Date: 1986-08-15 Impact factor: 3.857

2. 2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.

Authors: T M Kitson
Journal: Biochem J Date: 1979-12-01 Impact factor: 3.857

3. Evidence that the cytoplasmic aldehyde dehydrogenase-catalysed oxidation of aldehydes involves a different active-site group from that which catalyses the hydrolysis of 4-nitrophenyl acetate.

Authors: R L Motion; P D Buckley; A F Bennett; L F Blackwell
Journal: Biochem J Date: 1988-09-15 Impact factor: 3.857

7. Evidence that the slow conformation change controlling NADH release from the enzyme is rate-limiting during the oxidation of propionaldehyde by aldehyde dehydrogenase.

Authors: L F Blackwell; R L Motion; A K MacGibbon; M J Hardman; P D Buckley
Journal: Biochem J Date: 1987-03-15 Impact factor: 3.857

8. The coenzyme-binding characteristics of highly purified preparations of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors: G J Hart; F M Dickinson
Journal: Biochem J Date: 1983-05-01 Impact factor: 3.857