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Literature DB >> 21734116

Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages.

Kevin C Kobylinski¹, Massamba Sylla, Phillip L Chapman, Moussa D Sarr, Brian D Foy.

Abstract

Ivermectin mass drug administration (MDA) to humans is used to control onchocerciasis and lymphatic filariasis. Recent field studies have shown an added killing effect of ivermectin MDA against malaria vectors. We report that ivermectin MDA reduced the proportion of Plasmodium falciparum infectious Anopheles gambiae sensu stricto (s.s.) in treated villages in southeastern Senegal. Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. It could be a powerful and synergistic new tool to reduce malaria transmission in regions with epidemic or seasonal malaria transmission, and the prevalence and intensity of neglected tropical diseases.

Entities: Disease Species

Mesh：

Substances：
Antimalarials
Ivermectin

Year: 2011 PMID： 21734116 PMCID： PMC3122335 DOI： 10.4269/ajtmh.2011.11-0160

Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345

21 in total

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8. Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors.

Authors: Massamba Sylla; Kevin C Kobylinski; Meg Gray; Phillip L Chapman; Moussa D Sarr; Jason L Rasgon; Brian D Foy
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9. PCR-based detection of Plasmodium in Anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods.

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