Literature DB >> 21734052

Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis.

Chris Ka Pun Mok1, Hui Ling Yen, May Yan Mei Yu, Kit Man Yuen, Sin Fun Sia, Michael Chi Wai Chan, Gang Qin, Wen Wei Tu, Joseph Sriyal Malik Peiris.   

Abstract

We investigated the tropism, host responses, and virulence of two variants of A/Quail/Hong Kong/G1/1997 (H9N2) (H9N2/G1) with D253N and Q591K in the PB2 protein in primary human macrophages and bronchial epithelium in vitro and in mice in vivo. Virus with PB2 D253N and Q591K had greater polymerase activity in minireplicon assays, induced more tumor necrosis factor alpha (TNF-α) in human macrophages, replicated better in differentiated normal human bronchial epithelial (NHBE) cells, and was more pathogenic for mice. Taken together, our studies help define the viral genetic determinants that contribute to pathogenicity of H9N2 viruses.

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Year:  2011        PMID： 21734052      PMCID： PMC3165745          DOI： 10.1128/JVI.00702-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

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Journal:  Lancet       Date:  2002-12-07       Impact factor: 79.321

2.  Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003.

Authors:  K M Butt; Gavin J D Smith; Honglin Chen; L J Zhang; Y H Connie Leung; K M Xu; Wilina Lim; Robert G Webster; K Y Yuen; J S Malik Peiris; Yi Guan
Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

3.  Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model.

Authors:  Zejun Li; Hualan Chen; Peirong Jiao; Guohua Deng; Guobin Tian; Yanbing Li; Erich Hoffmann; Robert G Webster; Yumiko Matsuoka; Kangzhen Yu
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

4.  Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?

Authors:  J S Peiris; Y Guan; D Markwell; P Ghose; R G Webster; K F Shortridge
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

5.  Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?

Authors:  Y Guan; K F Shortridge; S Krauss; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

6.  Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates.

Authors:  Y P Lin; M Shaw; V Gregory; K Cameron; W Lim; A Klimov; K Subbarao; Y Guan; S Krauss; K Shortridge; R Webster; N Cox; A Hay
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

Review 7.  Reverse genetics of influenza virus.

Authors:  G Neumann; Y Kawaoka
Journal:  Virology       Date:  2001-09-01       Impact factor: 3.616

8.  Human infection with influenza H9N2.

Authors:  M Peiris; K Y Yuen; C W Leung; K H Chan; P L Ip; R W Lai; W K Orr; K F Shortridge
Journal:  Lancet       Date:  1999-09-11       Impact factor: 79.321

9.  PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice.

Authors:  Kyoko Shinya; Stefan Hamm; Masato Hatta; Hiroshi Ito; Toshihiro Ito; Yoshihiro Kawaoka
Journal:  Virology       Date:  2004-03-15       Impact factor: 3.616

10.  [Discovery of men infected by avian influenza A (H9N2) virus].

Authors:  Y Guo; J Li; X Cheng
Journal:  Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi       Date:  1999-06-30
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  35 in total

1.  Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

Authors:  Chris Ka Pun Mok; Horace Hok Yeung Lee; Maxime Lestra; John Malcolm Nicholls; Michael Chi Wai Chan; Sin Fun Sia; Huachen Zhu; Leo Lit Man Poon; Yi Guan; Joseph Sriyal Malik Peiris
Journal:  J Virol       Date:  2014-01-08       Impact factor: 5.103

2.  Pathogenicity and transmissibility of reassortant H9 influenza viruses with genes from pandemic H1N1 virus.

Authors:  Chuanling Qiao; Qinfang Liu; Bhupinder Bawa; Huigang Shen; Wenbao Qi; Ying Chen; Chris Ka Pun Mok; Adolfo García-Sastre; Jürgen A Richt; Wenjun Ma
Journal:  J Gen Virol       Date:  2012-08-08       Impact factor: 3.891

3.  A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells.

Authors:  Islam T M Hussein; Eric J Ma; Nichola J Hill; Brandt W Meixell; Mark Lindberg; Randy A Albrecht; Justin Bahl; Jonathan A Runstadler
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4.  Validation of normal human bronchial epithelial cells as a model for influenza A infections in human distal trachea.

Authors:  A Sally Davis; Daniel S Chertow; Jenna E Moyer; Jon Suzich; Aline Sandouk; David W Dorward; Carolea Logun; James H Shelhamer; Jeffery K Taubenberger
Journal:  J Histochem Cytochem       Date:  2015-01-20       Impact factor: 2.479

Review 5.  Transmission of influenza A viruses.

Authors:  Gabriele Neumann; Yoshihiro Kawaoka
Journal:  Virology       Date:  2015-03-24       Impact factor: 3.616

6.  Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015.

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7.  Isolation and full genome characterization of avian influenza subtype H9N2 from poultry respiratory disease outbreak in Egypt.

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Review 8.  H9 Influenza Viruses: An Emerging Challenge.

Authors:  Silvia Carnaccini; Daniel R Perez
Journal:  Cold Spring Harb Perspect Med       Date:  2020-06-01       Impact factor: 6.915

Review 9.  Connecting the study of wild influenza with the potential for pandemic disease.

Authors:  Jonathan Runstadler; Nichola Hill; Islam T M Hussein; Wendy Puryear; Mandy Keogh
Journal:  Infect Genet Evol       Date:  2013-03-26       Impact factor: 3.342

Review 10.  Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier.

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Journal:  J Virol       Date:  2013-04-24       Impact factor: 5.103
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