| Literature DB >> 27405930 |
Yuhai Bi1,2,3, Jianjun Chen4,5, Zhenjie Zhang6, Mingxin Li4, Tianlong Cai7, Kirill Sharshov5, Ivan Susloparov5, Alexander Shestopalov5, Gary Wong8, Yubang He9, Zhi Xing9, Jianqing Sun9, Di Liu8, Yingxia Liu10, Lei Liu10, Wenjun Liu8,11, Fumin Lei7,11, Weifeng Shi12, George F Gao10,8,11,13.
Abstract
A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.Entities:
Keywords: Clade 2.3.2.1c; H5N1; highly pathogenic avian influenza virus; migratory birds; outbreak
Mesh：
Year: 2016 PMID： 27405930 PMCID： PMC8193437 DOI： 10.1007/s12250-016-3750-4
Source DB: PubMed Journal: Virol Sin ISSN： 1995-820X Impact factor: 4.327