OBJECTIVE: Report a case of loss of cochlear implant benefit after cisplatin therapy to treat osteosarcoma. Examine the implications for the loci of cisplatin-associated cochleotoxicity. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Single case study. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cochlear implant programming levels. RESULTS: Increase in cochlear implant programming T- and C-levels after cisplatin therapy. CONCLUSION: Cisplatin therapy likely affects spiral ganglion cells. It seems that auditory cells other than outer hair cells in the organ of Corti are affected by cisplatin because the hearing sensitivity of this patient with nonfunctioning outer hair cells declined after receiving chemotherapy. Implications of these findings are discussed.
OBJECTIVE: Report a case of loss of cochlear implant benefit after cisplatin therapy to treat osteosarcoma. Examine the implications for the loci of cisplatin-associated cochleotoxicity. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Single case study. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cochlear implant programming levels. RESULTS: Increase in cochlear implant programming T- and C-levels after cisplatin therapy. CONCLUSION:Cisplatin therapy likely affects spiral ganglion cells. It seems that auditory cells other than outer hair cells in the organ of Corti are affected by cisplatin because the hearing sensitivity of this patient with nonfunctioning outer hair cells declined after receiving chemotherapy. Implications of these findings are discussed.
Authors: J R García-Berrocal; J Nevado; R Ramírez-Camacho; R Sanz; J A González-García; C Sánchez-Rodríguez; B Cantos; P España; J M Verdaguer; A Trinidad Cabezas Journal: Br J Pharmacol Date: 2007-10-01 Impact factor: 8.739
Authors: Theresa M Harned; Ondrej Kalous; Alexander Neuwelt; Jason Loera; Lingyun Ji; Peter Iovine; Richard Sposto; Edward A Neuwelt; C Patrick Reynolds Journal: Clin Cancer Res Date: 2008-01-15 Impact factor: 12.531
Authors: Yang Di; Tao Xu; Yuan Tian; Tingting Ma; Donghao Qu; Yan Wang; Yuhan Lin; Dongyan Bao; Li Yu; Shuangyue Liu; Aimei Wang Journal: Int J Mol Med Date: 2020-06-04 Impact factor: 4.101