Literature DB >> 21730123

Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections.

M A Ghannoum1, N Isham, M R Jacobs.   

Abstract

The triple combination trimethoprim, EDTA, and ethanol (B-Lock), is an antimicrobial lock solution for use in indwelling intravascular catheters to prevent and treat catheter-associated infections. B-Lock demonstrated MICs of ≤0.05% (percentage of solution) against Candida spp. (n = 125) and 0.003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections.

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Year:  2011        PMID： 21730123      PMCID： PMC3165356          DOI： 10.1128/AAC.00677-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

Review 1.  The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies.

Authors:  Dennis G Maki; Daniel M Kluger; Christopher J Crnich
Journal:  Mayo Clin Proc       Date:  2006-09       Impact factor: 7.616

2.  Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.

Authors:  Leonard A Mermel; Michael Allon; Emilio Bouza; Donald E Craven; Patricia Flynn; Naomi P O'Grady; Issam I Raad; Bart J A Rijnders; Robert J Sherertz; David K Warren
Journal:  Clin Infect Dis       Date:  2009-07-01       Impact factor: 9.079

3.  Strategies to prevent central line-associated bloodstream infections in acute care hospitals.

Authors:  Jonas Marschall; Leonard A Mermel; David Classen; Kathleen M Arias; Kelly Podgorny; Deverick J Anderson; Helen Burstin; David P Calfee; Susan E Coffin; Erik R Dubberke; Victoria Fraser; Dale N Gerding; Frances A Griffin; Peter Gross; Keith S Kaye; Michael Klompas; Evelyn Lo; Lindsay Nicolle; David A Pegues; Trish M Perl; Sanjay Saint; Cassandra D Salgado; Robert A Weinstein; Robert Wise; Deborah S Yokoe
Journal:  Infect Control Hosp Epidemiol       Date:  2008-10       Impact factor: 3.254

4.  Organic solvents as probes for the structure and function of the bacterial membrane: effects of ethanol on the wild type and an ethanol-resistant mutant of Escherichia coli K-12.

Authors:  V A Fried; A Novick
Journal:  J Bacteriol       Date:  1973-04       Impact factor: 3.490

5.  Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention.

Authors:  Naomi P O'Grady; Mary Alexander; E Patchen Dellinger; Julie L Gerberding; Stephen O Heard; Dennis G Maki; Henry Masur; Rita D McCormick; Leonard A Mermel; Michele L Pearson; Issam I Raad; Adrienne Randolph; Robert A Weinstein
Journal:  MMWR Recomm Rep       Date:  2002-08-09

6.  Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality.

Authors:  D Pittet; D Tarara; R P Wenzel
Journal:  JAMA       Date:  1994-05-25       Impact factor: 56.272

7.  Use of maximal sterile barriers during central venous catheter insertion: clinical and economic outcomes.

Authors:  Kent K Hu; David L Veenstra; Benjamin A Lipsky; Sanjay Saint
Journal:  Clin Infect Dis       Date:  2004-10-18       Impact factor: 9.079
  7 in total
  10 in total

1.  Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy.

Authors:  Ashwini Chauhan; David Lebeaux; Jean-Marc Ghigo; Christophe Beloin
Journal:  Antimicrob Agents Chemother       Date:  2012-10-01       Impact factor: 5.191

Review 2.  Antifungal lock therapy.

Authors:  Carla J Walraven; Samuel A Lee
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

3.  EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by Cryptococcus neoformans.

Authors:  Emma J Robertson; Julie M Wolf; Arturo Casadevall
Journal:  Appl Environ Microbiol       Date:  2012-08-31       Impact factor: 4.792

4.  Fungal biofilm resistance.

Authors:  Gordon Ramage; Ranjith Rajendran; Leighann Sherry; Craig Williams
Journal:  Int J Microbiol       Date:  2012-02-08

5.  S-Nitroso-N-acetyl-l-cysteine Ethyl Ester (SNACET) Catheter Lock Solution to Reduce Catheter-Associated Infections.

Authors:  Rajnish Kumar; Hamed Massoumi; Manjyot Kaur Chug; Elizabeth J Brisbois
Journal:  ACS Appl Mater Interfaces       Date:  2021-05-24       Impact factor: 10.383

6.  Ethanol lock therapy (E-Lock) in the prevention of catheter-related bloodstream infections (CR-BSI) after major heart surgery (MHS): a randomized clinical trial.

Authors:  María Jesús Pérez-Granda; José María Barrio; Patricia Muñoz; Javier Hortal; Cristina Rincón; Pablo Martin Rabadán; Maria Sagrario Pernia; Emilio Bouza
Journal:  PLoS One       Date:  2014-03-27       Impact factor: 3.240

Review 7.  Antibiotic lock therapy: review of technique and logistical challenges.

Authors:  Julie Ann Justo; P Brandon Bookstaver
Journal:  Infect Drug Resist       Date:  2014-12-12       Impact factor: 4.003

Review 8.  Approaches for Mitigating Microbial Biofilm-Related Drug Resistance: A Focus on Micro- and Nanotechnologies.

Authors:  Harinash Rao; Sulin Choo; Sri Raja Rajeswari Mahalingam; Diajeng Sekar Adisuri; Priya Madhavan; Abdah Md Akim; Pei Pei Chong
Journal:  Molecules       Date:  2021-03-26       Impact factor: 4.411

Review 9.  Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?

Authors:  R Kovács; L Majoros
Journal:  Lett Appl Microbiol       Date:  2022-01-30       Impact factor: 2.813

10.  Antimicrobial Activity of a Vaginal Gel Formulation: Considerations Related to Vaginal Infection and Dysbiosis.

Authors:  Francesco De Seta; Bryan Larsen
Journal:  Pathogens       Date:  2021-12-03
  10 in total

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