| Literature DB >> 21726937 |
Shigeki Yagyu1, Tomoko Iehara, Takahiro Gotoh, Mitsuru Miyachi, Yoshiki Katsumi, Ken Kikuchi, Kunihiko Tsuchiya, Shinya Osone, Hiroshi Kuroda, Tohru Sugimoto, Tadashi Sawada, Hajime Hosoi.
Abstract
Allelic deletion of the long arm of chromosome 11 (11q loss) is closely associated with the prognosis of neuroblastoma (NB). Here we examined 11q loss using tumor-released DNA fragments in the sera of 24 cases. The allelic intensity score of a panel of polymorphic markers in 11q23 in serum DNA was significantly different between the 11q loss-positive group and the11q loss-negative group. The 11q loss-positive and -negative groups did not overlap when a cut-off value of 0.5 was chosen for the allelic intensity score. Our serum-based 11q loss analysis could predict the allelic status of 11q in tumors.Entities:
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Year: 2011 PMID： 21726937 DOI： 10.1016/j.canlet.2011.05.032
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679