UNLABELLED: Modeled attenuation correction (AC) will be necessary for combined PET/MRI scanners not equipped with transmission scanning hardware. We compared 2 modeled AC approaches that use nonrigid registration with rotating (68)Ge rod-based measured AC for 10 subjects scanned with (18)F-FDG. METHODS: Two MRI and attenuation map pairs were evaluated: tissue atlas-based and measured templates. The tissue atlas approach used a composite of the BrainWeb and Zubal digital phantoms, whereas the measured templates were produced by averaging spatially normalized measured MR image and coregistered attenuation maps. The composite digital phantom was manually edited to include 2 additional tissue classes (paranasal sinuses, and ethmoidal air cells or nasal cavity). In addition, 3 attenuation values for bone were compared. The MRI and attenuation map pairs were used to generate subject-specific attenuation maps via nonrigid registration of the MRI to the MR image of the subject. SPM2 and a B-spline free-form deformation algorithm were used for the nonrigid registration. To determine the accuracy of the modeled AC approaches, radioactivity concentration was assessed on a voxelwise and regional basis. RESULTS: The template approach produced better spatial consistency than the phantom-based atlas, with an average percentage error in radioactivity concentration across the regions, compared with measured AC, of -1.2% ± 1.2% and -1.5% ± 1.9% for B-spline and SPM2 registration, respectively. In comparison, the tissue atlas method with B-spline registration produced average percentage errors of 0.0% ± 3.0%, 0.9% ± 2.9%, and 2.9% ± 2.8% for bone attenuation values of 0.143 cm(-1), 0.152 cm(-1), and 0.172 cm(-1), respectively. The largest errors for the template AC method were found in parts of the frontal cortex (-3%) and the cerebellar vermis (-5%). Intersubject variability was higher with SPM2 than with B-spline. Compared with measured AC, template AC with B-spline and SPM2 achieved a correlation coefficient (R(2)) of 0.99 and 0.98, respectively, for regional radioactivity concentration. The corresponding R(2) for the tissue atlas approach with B-spline registration was 0.98, irrespective of the bone attenuation coefficient. CONCLUSION: Nonrigid registration of joint MRI and attenuation map templates can produce accurate AC for brain PET scans, particularly with measured templates and B-spline registration. Consequently, these methods are suitable for AC of brain scans acquired on combined PET/MRI systems.
UNLABELLED: Modeled attenuation correction (AC) will be necessary for combined PET/MRI scanners not equipped with transmission scanning hardware. We compared 2 modeled AC approaches that use nonrigid registration with rotating (68)Ge rod-based measured AC for 10 subjects scanned with (18)F-FDG. METHODS: Two MRI and attenuation map pairs were evaluated: tissue atlas-based and measured templates. The tissue atlas approach used a composite of the BrainWeb and Zubal digital phantoms, whereas the measured templates were produced by averaging spatially normalized measured MR image and coregistered attenuation maps. The composite digital phantom was manually edited to include 2 additional tissue classes (paranasal sinuses, and ethmoidal air cells or nasal cavity). In addition, 3 attenuation values for bone were compared. The MRI and attenuation map pairs were used to generate subject-specific attenuation maps via nonrigid registration of the MRI to the MR image of the subject. SPM2 and a B-spline free-form deformation algorithm were used for the nonrigid registration. To determine the accuracy of the modeled AC approaches, radioactivity concentration was assessed on a voxelwise and regional basis. RESULTS: The template approach produced better spatial consistency than the phantom-based atlas, with an average percentage error in radioactivity concentration across the regions, compared with measured AC, of -1.2% ± 1.2% and -1.5% ± 1.9% for B-spline and SPM2 registration, respectively. In comparison, the tissue atlas method with B-spline registration produced average percentage errors of 0.0% ± 3.0%, 0.9% ± 2.9%, and 2.9% ± 2.8% for bone attenuation values of 0.143 cm(-1), 0.152 cm(-1), and 0.172 cm(-1), respectively. The largest errors for the template AC method were found in parts of the frontal cortex (-3%) and the cerebellar vermis (-5%). Intersubject variability was higher with SPM2 than with B-spline. Compared with measured AC, template AC with B-spline and SPM2 achieved a correlation coefficient (R(2)) of 0.99 and 0.98, respectively, for regional radioactivity concentration. The corresponding R(2) for the tissue atlas approach with B-spline registration was 0.98, irrespective of the bone attenuation coefficient. CONCLUSION: Nonrigid registration of joint MRI and attenuation map templates can produce accurate AC for brain PET scans, particularly with measured templates and B-spline registration. Consequently, these methods are suitable for AC of brain scans acquired on combined PET/MRI systems.
Authors: David Izquierdo-Garcia; Stephen J Sawiak; Karin Knesaurek; Jagat Narula; Valentin Fuster; Joseph Machac; Zahi A Fayad Journal: Eur J Nucl Med Mol Imaging Date: 2014-03-21 Impact factor: 9.236
Authors: Andrew P Leynes; Jaewon Yang; Florian Wiesinger; Sandeep S Kaushik; Dattesh D Shanbhag; Youngho Seo; Thomas A Hope; Peder E Z Larson Journal: J Nucl Med Date: 2017-10-30 Impact factor: 10.057
Authors: Anne Larsson; Adam Johansson; Jan Axelsson; Tufve Nyholm; Thomas Asklund; Katrine Riklund; Mikael Karlsson Journal: MAGMA Date: 2012-09-07 Impact factor: 2.310
Authors: Patrick Veit-Haibach; Felix Pierre Kuhn; Florian Wiesinger; Gaspar Delso; Gustav von Schulthess Journal: MAGMA Date: 2012-10-09 Impact factor: 2.310
Authors: Kevin T Chen; David Izquierdo-Garcia; Clare B Poynton; Daniel B Chonde; Ciprian Catana Journal: Eur J Nucl Med Mol Imaging Date: 2016-08-29 Impact factor: 9.236