AIM: To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. METHODS: All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. RESULTS: Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100,000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100,000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100,000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. CONCLUSION: The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.
AIM: To determine the prevalence and incidence of diagnosed coeliac disease (CD) in Danish children and adolescents and to describe trends over time. METHODS: All children with a CD diagnosis registered in the Danish National Patient Registry (DNPR) were included in the study. Data were validated by combining this information with registrations of small-bowel biopsies in the National Registry of Pathology (NRP) and with a selected sample of hospital records. RESULTS: Data were obtained from 1996 to 2010. The prevalence of CD registered in DNPR increased from 43.2 [95% CI 39.3-47.1] to 83.6 [95% CI 78.4-88.7] per 100,000, and the incidence increased from 2.8 [95% CI 1.9-3.9] to 10.0 [95% CI 8.4-12.0] per 100,000; 56% of the children had at least one biopsy compatible with CD registered in NRP. The incidence of biopsy-verified CD increased from 0.8 [95% CI 0.3-1.4] to 6.9 [95% CI 5.4-8.4] per 100,000. The mean age at diagnosis increased from 5.1 [95% CI 3.5-6.6] to 8.1 [95% CI 7.2-9.0] years of age. The proportion of children with associated diseases did not change over time. CONCLUSION: The prevalence of diagnosed CD in Danish children and adolescents has increased over the last 15 years.
Authors: Rok Seon Choung; Ivo C Ditah; Ashley M Nadeau; Alberto Rubio-Tapia; Eric V Marietta; Tricia L Brantner; Michael J Camilleri; S Vincent Rajkumar; Ola Landgren; James E Everhart; Joseph A Murray Journal: Am J Gastroenterol Date: 2015-02-10 Impact factor: 10.864
Authors: Line Lund Kårhus; Tea Skaaby; Anja Lykke Madsen; Betina Heinsbæk Thuesen; Peter Schwarz; Jüri J Rumessen; Allan Linneberg Journal: United European Gastroenterol J Date: 2018-11-05 Impact factor: 4.623
Authors: Lars E Bartels; Peter Jepsen; Lisbet A Christensen; Lars U Gerdes; Hendrik Vilstrup; Jens F Dahlerup Journal: J Crohns Colitis Date: 2015-12-16 Impact factor: 9.071