Lars E Bartels1, Peter Jepsen2, Lisbet A Christensen3, Lars U Gerdes4, Hendrik Vilstrup3, Jens F Dahlerup3. 1. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark larsbart@rm.dk. 2. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. 3. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. 4. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Abstract
BACKGROUND AND AIMS: Helicobacter pylori infection may protect against some chronic inflammatory diseases. This study examined H. pylori infection and its association with the prevalence of the gastrointestinal diseases Crohn's disease [CD], ulcerative colitis [UC], and coeliac disease [CeD]. Incident cases in a follow-up period after H. pylori testing were recorded to investigate if protective effects of H. pylori persisted after probable eradication. METHODS: This was a historical cohort study performed in the Central Denmark Region. Patients were enrolled consecutively from primary health care centres after a urea breath test [UBT] for H. pylori and were then followed for a median of 6 years. The patient's diseases, country of birth, and gender were acquired from nationwide administrative registries. We used logistic regression to compare the prevalences of CD, UC, and CeD and Cox regression to compare the incidences of CD, UC, and CeD between H. pylori-positive and H. pylori-negative patients, adjusting for confounding variables. RESULTS: We found a lower prevalence of CD in H. pylori-positive than in H. pylori-negative patients (odds ratio = 0.36 [0.17-0.75]). There were fewer incident cases of CD in H. pylori-positive than H. pylori-negative patients in the follow-up period (hazard ratio = 0.59 [0.36-0.96]). Similar trends were found for CeD but not for UC. CONCLUSIONS: H. pylori infection may be a protective factor against the development of CD. However, the incidence of CD is still reduced after UBT and probable H. pylori eradication; thus, H. pylori status may be a marker for other factors that protect against CD.
BACKGROUND AND AIMS: Helicobacter pyloriinfection may protect against some chronic inflammatory diseases. This study examined H. pyloriinfection and its association with the prevalence of the gastrointestinal diseases Crohn's disease [CD], ulcerative colitis [UC], and coeliac disease [CeD]. Incident cases in a follow-up period after H. pylori testing were recorded to investigate if protective effects of H. pylori persisted after probable eradication. METHODS: This was a historical cohort study performed in the Central Denmark Region. Patients were enrolled consecutively from primary health care centres after a urea breath test [UBT] for H. pylori and were then followed for a median of 6 years. The patient's diseases, country of birth, and gender were acquired from nationwide administrative registries. We used logistic regression to compare the prevalences of CD, UC, and CeD and Cox regression to compare the incidences of CD, UC, and CeD between H. pylori-positive and H. pylori-negative patients, adjusting for confounding variables. RESULTS: We found a lower prevalence of CD in H. pylori-positive than in H. pylori-negative patients (odds ratio = 0.36 [0.17-0.75]). There were fewer incident cases of CD in H. pylori-positive than H. pylori-negative patients in the follow-up period (hazard ratio = 0.59 [0.36-0.96]). Similar trends were found for CeD but not for UC. CONCLUSIONS:H. pyloriinfection may be a protective factor against the development of CD. However, the incidence of CD is still reduced after UBT and probable H. pylori eradication; thus, H. pylori status may be a marker for other factors that protect against CD.
Authors: Peter Malfertheiner; Francis Megraud; Colm A O'Morain; John Atherton; Anthony T R Axon; Franco Bazzoli; Gian Franco Gensini; Javier P Gisbert; David Y Graham; Theodore Rokkas; Emad M El-Omar; Ernst J Kuipers Journal: Gut Date: 2012-05 Impact factor: 23.059
Authors: Roland Rad; Lena Brenner; Stefan Bauer; Susanne Schwendy; Laura Layland; Clarissa Prazeres da Costa; Wolfgang Reindl; Anar Dossumbekova; Mathias Friedrich; Dieter Saur; Hermann Wagner; Roland M Schmid; Christian Prinz Journal: Gastroenterology Date: 2006-08 Impact factor: 22.682
Authors: Lars E Bartels; Alma B Pedersen; Nickolaj R Kristensen; Hendrik Vilstrup; Kristian Stengaard-Pedersen; Jens F Dahlerup Journal: Rheumatol Int Date: 2019-12-04 Impact factor: 2.631