BACKGROUND: The mechanism for loss of myeloid dendritic cells (mDCs) from the circulation in HIV-infected individuals and its relationship to disease progression is not understood. METHODS: A longitudinal analysis of the mDC response in blood and lymph nodes during the first 12 weeks of infection was performed in a cohort of SIVmac251-infected rhesus macaques with different disease outcomes. RESULTS: Monkeys that rapidly progressed to disease or had long-term stable infection had significant losses or increases, respectively, in blood mDCs that were inversely correlated with virus load at set-point. The loss of mDCs from progressor animals was associated with evidence of an increase in CCR7/CCL19-dependent mDC recruitment to lymph nodes and an increase in mDC apoptosis. CONCLUSIONS: mDC recruitment to and death within inflamed lymph nodes may contribute to disease progression in SIV infection, whereas mobilization without increased recruitment to lymph nodes may promote disease control.
BACKGROUND: The mechanism for loss of myeloid dendritic cells (mDCs) from the circulation in HIV-infected individuals and its relationship to disease progression is not understood. METHODS: A longitudinal analysis of the mDC response in blood and lymph nodes during the first 12 weeks of infection was performed in a cohort of SIVmac251-infected rhesus macaques with different disease outcomes. RESULTS: Monkeys that rapidly progressed to disease or had long-term stable infection had significant losses or increases, respectively, in blood mDCs that were inversely correlated with virus load at set-point. The loss of mDCs from progressor animals was associated with evidence of an increase in CCR7/CCL19-dependent mDC recruitment to lymph nodes and an increase in mDC apoptosis. CONCLUSIONS:mDC recruitment to and death within inflamed lymph nodes may contribute to disease progression in SIV infection, whereas mobilization without increased recruitment to lymph nodes may promote disease control.
Authors: J Pacanowski; S Kahi; M Baillet; P Lebon; C Deveau; C Goujard; L Meyer; E Oksenhendler; M Sinet; A Hosmalin Journal: Blood Date: 2001-11-15 Impact factor: 22.113
Authors: Michael I Zimmer; Adriana T Larregina; Cielo M Castillo; Saverio Capuano; Louis D Falo; Michael Murphey-Corb; Todd A Reinhart; Simon M Barratt-Boyes Journal: Blood Date: 2002-04-15 Impact factor: 22.113
Authors: Karin Loré; Anders Sönnerborg; Christina Broström; Li-Ean Goh; Luc Perrin; Hugh McDade; Hans-Jürgen Stellbrink; Brian Gazzard; Rainer Weber; Laura A Napolitano; Yvette van Kooyk; Jan Andersson Journal: AIDS Date: 2002-03-29 Impact factor: 4.177
Authors: Michelle A Barron; Naomi Blyveis; Brent E Palmer; Samantha MaWhinney; Cara C Wilson Journal: J Infect Dis Date: 2002-12-13 Impact factor: 5.226
Authors: William D Cornwell; Wendeline Wagner; Mark G Lewis; Xiaoxuan Fan; Jay Rappaport; Thomas J Rogers Journal: J Neuroimmunol Date: 2016-04-16 Impact factor: 3.478
Authors: Viskam Wijewardana; Jan Kristoff; Cuiling Xu; Dongzhu Ma; George Haret-Richter; Jennifer L Stock; Benjamin B Policicchio; Adam D Mobley; Rebecca Nusbaum; Hadega Aamer; Anita Trichel; Ruy M Ribeiro; Cristian Apetrei; Ivona Pandrea Journal: PLoS Pathog Date: 2013-10-03 Impact factor: 6.823