| Literature DB >> 27235346 |
William D Cornwell1, Wendeline Wagner2, Mark G Lewis2, Xiaoxuan Fan3, Jay Rappaport4, Thomas J Rogers5.
Abstract
We studied the effect of chronic morphine administration on the circulating dendritic cell population dynamics associated with SIV infection using rhesus macaques. Animals were either first infected with SIV and then given chronic morphine, or visa versa. SIV infection increased the numbers of myeloid DCs (mDCs), but morphine treatment attenuated this mDC expansion. In contrast, morphine increased the numbers of plasmacytoid DCs (pDCs) in SIV-infected animals. Finally, chronic morphine administration (no SIV) transiently increased the numbers of circulating pDCs. These results show that chronic morphine induces a significant alteration in the available circulating levels of critical antigen-presenting cells.Entities:
Keywords: CD83; Dendritic cells; Morphine; Myeloid; Plasmacytoid; SIV
Mesh:
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Year: 2016 PMID: 27235346 PMCID: PMC4884613 DOI: 10.1016/j.jneuroim.2016.04.007
Source DB: PubMed Journal: J Neuroimmunol ISSN: 0165-5728 Impact factor: 3.478